ReviewHeart failure reviews2008
Iron and anemia in human biology: a review of mechanisms.
Review in Heart failure reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.
- Serum or plasma ferritin concentration as an index of iron deficiency and overload.The Cochrane database of systematic reviews · 2021Pooled it
- Oral Supplementation with Sucrosomial Ferric Pyrophosphate Plus L-Ascorbic Acid to Ameliorate the Martial Status: A Randomized Controlled Trial.Nutrients · 2020Trial
- Monthly administration of a continuous erythropoietin receptor activator provides efficient haemoglobin control in non-dialysis patients during routine clinical practice: results from the non-interventional, single-cohort, multicentre, SUPRA study.Clinical drug investigation · 2012Trial
- Erythrocyte Membrane Fatty Acid Remodeling and Zinc Protoporphyrin Alterations Associated with Anemia Severity in Hemodialysis Patients.Biomedicines · 2026Article
- Effects of post-farrowing feed delivery schedule and sow parity on piglet performance and survivabilityTranslational animal science · 2026Article
- Molecular Mechanisms of Iron Metabolism and Overload.Biomedicines · 2025Review
- [Changes of parameters associated with anemia of inflammation in patients with stage Ⅲ periodontitis before and after periodontal initial therapy].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Cardiorenal Syndrome: Challenges in Everyday Clinical Practice and Key Points towards a Better Management.Journal of clinical medicine · 2023Review
- Individual and contextual-level factors associated with iron-folic acid supplement intake during pregnancy in Ethiopia: a multi-level analysis.BMC pregnancy and childbirth · 2023Article
- Investigation of extracellular medium osmolality depending on zinc application and incubation time on A549 cancer cells.Journal of biological physics · 2022Article
- Zinc protoporphyrin levels in COVID-19 are indicative of iron deficiency and potential predictor of disease severity.PloS one · 2022Article
- Association between obesity and iron deficiency (Review).Experimental and therapeutic medicine · 2021Review
- Article
- Iron deficiency as therapeutic target in heart failure: a translational approach.Heart failure reviews · 2020Review
- Study on Chemical Modifications of Glutathione by Cold Atmospheric Pressure Plasma (Cap) Operated in Air in the Presence of Fe(II) and Fe(III) Complexes.Scientific reports · 2019Article
- Monitoring of iron status in patients with heart failure.European heart journal supplements : journal of the European Society of Cardiology · 2019Article
- Intravenous iron therapy for patients with heart failure: expanding body of evidence.ESC heart failure · 2019Article
- Anemia profile in patients with congestive heart failure a hospital based observational study.Indian heart journal · 2018Observational
- Haematopoietic effects of Angelica sinensis root cap polysaccharides against lisinopril-induced anaemia in albino rats.Pharmaceutical biology · 2017Article
- Recovery from dietary iron deficiency anaemia in rats by the intake of microencapsulated ferric saccharate.Journal of food science and technology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biology of iron in relation to anemia is best understood by a review of the iron cycle, since the majority of iron for erythropoiesis is provided by iron recovered from senescent erythrocytes. In iron-deficiency anemia, storage iron declines until iron delivery to the bone marrow is insufficient for erythropoiesis. This can be monitored with clinical indicators, beginning with low plasma ferritin, followed by decreased plasma iron and transferrin saturation, and culminating in red blood cells with low-Hb content. When adequate dietary iron is provided, these markers show return to normal, indicating a response to the dietary supplement. Anemia of inflammation (also known as anemia of chronic disease, or ACD) follows a different course, because in this form of anemia storage iron is often abundant but not available for erythropoiesis. The diagnosis of ACD is more difficult than the diagnosis of iron-deficiency anemia, and often the first identified symptom is the failure to show a response to a dietary iron supplement. Confirmation of ACD is best obtained from elevated markers of inflammation. The treatment of ACD, which typically employs erythropoietin (EPO) supplements and intravenous iron (i.v.-iron), is empirical and often falls shorts of therapeutic goals. Dialysis patients show a complex pattern of anemia, which results from inadequate EPO production by the kidney, inflammation, changes in nutrition, and blood losses during treatment. EPO and i.v.-iron are the mainstays of treatment. Patients with heart failure can be anemic, with incidence as high as 50%. The causes are multifactorial; inflammation now appears to be the primary cause of this form of anemia, with contributions from increased plasma volume, effects of drug therapy, and other complications of heart disease. Discerning the mechanisms of anemia for the heart failure patient may aid rational therapy in each case.
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