ArticleBehavior genetics2008
Rapid selection response for contextual fear conditioning in a cross between C57BL/6J and A/J: behavioral, QTL and gene expression analysis.
Article in Behavior genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- A systems approach identifies networks and genes linking sleep and stress: implications for neuropsychiatric disorders.Cell reports · 2015Article
- Predictability and heritability of individual differences in fear learning.Animal cognition · 2014Article
- A large QTL for fear and anxiety mapped using an F2 cross can be dissected into multiple smaller QTLs.Genes, brain, and behavior · 2013Article
- Preventing formation of reticulon 3 immunoreactive dystrophic neurites improves cognitive function in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Genome-wide association for fear conditioning in an advanced intercross mouse line.Behavior genetics · 2012Article
- Heritability and genetic correlations of fear-related behaviour in Red Junglefowl--possible implications for early domestication.PloS one · 2012Article
- Article
- Gene networks associated with conditional fear in mice identified using a systems genetics approach.BMC systems biology · 2011Article
- Brain transcriptomic response of threespine sticklebacks to cues of a predator.Brain, behavior and evolution · 2011Article
- Genomic mapping of social behavior traits in a F2 cross derived from mice selectively bred for high aggression.BMC genetics · 2010Article
- Article
- QTL underlying voluntary exercise in mice: interactions with the "mini muscle" locus and sex.The Journal of heredityArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We used short-term selection to produce outbred mouse lines with differences in contextual fear conditioning. Within two generations of selection all low selected mice were homozygous for the recessive tyrc allele and showed the corresponding albino coat color. Freezing differed in the high and low selected lines across a range of parameters. We identified several QTLs for the selection response, including a highly significant QTL at the tyr locus (p < 9.6(-10)). To determine whether the tyrc allele was directly responsible for the response to selection, we examined B6 mice that have a mutant tyr allele (tyr(c-2j-)) and an AJ congenic strain that has the wild-type B6 allele for tyr. These studies showed that the tyr allele had a small influence on fear learning. We used Affymetrix microarrays to identify many differentially expressed genes in the amygdala and hippocampus of the selected lines. We conclude that tyr is one of many alleles that influence fear conditioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.