ArticleLaboratory investigation; a journal of technical methods and pathology2008
Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma.
Article in Laboratory investigation; a journal of technical methods and pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- Disulfidptosis-related signature elucidates the prognostic, immunologic, and therapeutic characteristics in ovarian cancer.Frontiers in genetics · 2024Article
- ACTN1 interacts with ITGA5 to promote cell proliferation, invasion and epithelial-mesenchymal transformation in head and neck squamous cell carcinoma.Iranian journal of basic medical sciences · 2023Article
- Targeting Microtubule-Associated Protein Tau in Chemotherapy-Resistant Models of High-Grade Serous Ovarian Carcinoma.Cancers · 2022Article
- The mechanobiome: a goldmine for cancer therapeutics.American journal of physiology. Cell physiology · 2021Review
- Replicative senescence in MSCWJ-1 human umbilical cord mesenchymal stem cells is marked by characteristic changes in motility, cytoskeletal organization, and RhoA localization.Molecular biology reports · 2020Article
- A Context-Dependent Role for MiR-124-3p on Cell Phenotype, Viability and Chemosensitivity in NeuroblastomaFrontiers in cell and developmental biology · 2020Article
- Review
- Collagen-based three-dimensional culture microenvironment promotes epithelial to mesenchymal transition and drug resistance of human ovarian cancerRSC advances · 2018Article
- RNA editing ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Research advances on structure and biological functions of integrins.SpringerPlus · 2016Review
- ACTN4 and the pathways associated with cell motility and adhesion contribute to the process of lung cancer metastasis to the brain.BMC cancer · 2015Article
- MTBP inhibits migration and metastasis of hepatocellular carcinoma.Clinical & experimental metastasis · 2015Article
- Three-dimensional collagen type I matrix up-regulates nuclear isoforms of the microtubule associated protein tau implicated in resistance to paclitaxel therapy in ovarian carcinoma.International journal of molecular sciences · 2015Article
- α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation.PloS one · 2015Article
- The actinin family of actin cross-linking proteins - a genetic perspective.Cell & bioscience · 2015Article
- Identification of protein biomarkers for cervical cancer using human cervicovaginal fluid.PloS one · 2014Article
- Versican regulates metastasis of epithelial ovarian carcinoma cells and spheroids.Journal of ovarian research · 2014Article
- Actinin-4 in keratinocytes regulates motility via an effect on lamellipodia stability and matrix adhesions.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Advanced and metastatic ovarian cancer is a leading cause of death from gynecologic malignancies. A more detailed understanding of the factors controlling invasion and metastasis may lead to novel anti-metastatic therapies. To model cellular interactions that occur during intraperitoneal metastasis, comparative cDNA microarray analysis and confirmatory real-time reverse transcription PCR (RT-PCR) were employed to uncover changes in gene expression that may occur in late stage ovarian cancer in response to microenvironmental cues, particularly native three-dimensional collagen I. Gene expression in human ovarian carcinoma tissues was evaluated on the RNA and protein level using real-time RT-PCR and immunohistochemistry. Cell invasion and migration were evaluated in a collagen invasion assay and a scratch wound assay. Three-dimensional collagen I culture led to differential expression of several genes. The role of actinin alpha-4 (ACTN4), a cytoskeleton-associated protein implicated in the regulation of cell motility, was examined in detail. ACTN4 RNA and protein expression were associated with advanced and metastatic human ovarian carcinoma. This report demonstrates that a cytoskeletal-associated protein ACTN4 is upregulated by three-dimensional collagen culture conditions, leading to increased invasion and motility of ovarian cancer cells. Expression of ACTN4 in human ovarian tumors was found to be associated with advanced-stage disease and peritoneal metastases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.