ArticleBritish journal of pharmacology2008
Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET(B) receptor-mediated G(i)- and G(q)-pathways and MAP kinase activation.
Article in British journal of pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- Involvement of Mitophagy in Endothelin-1 Mediated Neurodegeneration in Rodent Models of Glaucoma.bioRxiv : the preprint server for biology · 2026Article
- Central regulation of body fluid homeostasis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2022Review
- A seven-gene signature and the C-C motif chemokine receptor family genes are the sarcoma-related immune genes.Bioengineered · 2021Article
- Endothelin ETInternational journal of molecular sciences · 2021Review
- Investigation of the Molecular Mechanisms by Which Endothelin-3 Stimulates Preadipocyte Growth.Frontiers in endocrinology · 2021Article
- A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells.PloS one · 2017Article
- Epigenetic silencing of endothelin-3 in colorectal cancer.International journal of immunopathology and pharmacology · 2016Article
- Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death.Biochemical pharmacology · 2016Article
- Behavioral and molecular processing of visceral pain in the brain of mice: impact of colitis and psychological stress.Frontiers in behavioral neuroscience · 2015Article
- Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways.Nitric oxide : biology and chemistry · 2014Review
- 15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis.International journal of cardiology · 2014Article
- LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis.Biochimie · 2012Article
- Article
- Four and a half LIM protein 1C (FHL1C): a binding partner for voltage-gated potassium channel K(v1.5).PloS one · 2011Article
- Mechanism of cancer pain.Molecular interventions · 2010Review
- Differential endothelin receptor expression and function in rat myometrial cells and leiomyoma ELT3 cells.Endocrinology · 2009Article
- Afamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrier.Journal of neurochemistry · 2009Article
- Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover.Clinical & experimental metastasis · 2009Review
- Regulation of the epithelial Na+ channel by endothelin-1 in rat collecting duct.American journal of physiology. Renal physiology · 2008Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeEndothelins (ETs) and their G protein-coupled receptors exert key physiological functions during normal and aberrant placental development. Trophoblast cells mediate the contact between the embryo and the mother, by establishing a transient organ, the placenta. Choriocarcinoma cells display many of the biochemical and morphological characteristics of in utero invasive trophoblast cells and may therefore be used as a suitable model to study epithelial tumour progression of foetal-derived cells. EXPERIMENTAL APPROACH: The present study aimed at investigating ET receptor-mediated activation of the mitogen-activated protein kinase (MAPK) pathway in human choriocarcinoma. KEY
resultsBoth JAR and Jeg-3 choriocarcinoma cell lines expressed ET receptor subtype B (ET(B)) but not ET(A) receptor transcripts. ET(B) receptor engagement by ET-1 and ET-3 resulted in a similar time- and concentration-dependent phosphorylation of p42/44 MAPK, also known as extracellular regulated kinase 1/2. Using specific pharmacological antagonists/inhibitors, we showed that ET-1/-3-mediated signal transduction by the ET(B) receptor is transmitted via G(i)- and G(q)-dependent pathways through activation of the Src (G(i)) and protein kinase C (G(q)) axis that converge at Ras/Raf, leading to downstream activation of p42/44. On a functional level, ET(B) engagement and subsequent phosphorylation of p42/44 resulted in enhanced transcription of the immediate early response genes c-fos and c-jun, a process commonly assumed to be mediated by the ET(A) receptor, and increased cell growth and relative cell area. CONCLUSIONS AND IMPLICATIONS: As human choriocarcinoma cells secrete ETs, pharmacological antagonism of ETs and/or ET(B) receptor-mediated signal transduction could represent a likely target therapy for choriocarcinoma.
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