ArticleJournal of lipid research2008
Candidate genes for plasma triglyceride, FFA, and glucose revealed from an intercross between inbred mouse strains NZB/B1NJ and NZW/LacJ.
Article in Journal of lipid research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
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- Assessing Population Structure and Signatures of Selection in Wanbei Pigs Using Whole Genome Resequencing Data.Animals : an open access journal from MDPI · 2022Article
- Genetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice.Genes · 2022Article
- Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study.The pharmacogenomics journal · 2021Article
- Whole genome detection of recent selection signatures in Sarabi cattle: a unique Iranian taurine breed.Genes & genomics · 2020Article
- Mapping and Congenic Dissection of Genetic Loci Contributing to Hyperglycemia and Dyslipidemia in Mice.PloS one · 2016Article
- Multilevel control of glucose homeostasis by adenylyl cyclase 8.Diabetologia · 2015Article
- Using bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ x SM/J intercross.Journal of lipid research · 2012Article
- Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice.Journal of lipid research · 2011Article
- Untangling HDL quantitative trait loci on mouse chromosome 5 and identifying Scarb1 and Acads as the underlying genes.Journal of lipid research · 2010Article
- TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.Diabetes · 2009Article
- Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene.Journal of lipid research · 2009Article
- Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice.Journal of lipid research · 2009Article
- Farp2 and Stk25 are candidate genes for the HDL cholesterol locus on mouse chromosome 1.Arteriosclerosis, thrombosis, and vascular biology · 2009Article
- Differences in DBA/1J and DBA/2J reveal lipid QTL genes.Journal of lipid research · 2008Article
- Differential sensitivity of mouse strains to an N-alkylated imino sugar: glycosphingolipid metabolism and acrosome formation.Pharmacogenomics · 2008Review
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
To identify the genes controlling plasma concentrations of triglycerides (TGs), FFAs, and glucose, we carried out a quantitative trait loci (QTL) analysis of the closely related mouse strains New Zealand Black (NZB/B1NJ) and New Zealand White (NZW/LacJ), which share 63% of their genomes. The NZB x NZW F(2) progeny were genotyped and phenotyped to detect QTL, and then comparative genomics, bioinformatics, and sequencing were used to narrow the QTL and reduce the number of candidate genes. Triglyceride concentrations were linked to loci on chromosomes (Chr) 4, 7, 8, 10, and 18. FFA concentrations were affected by a significant locus on Chr 4, a suggestive locus on Chr 16, and two interacting loci on Chr 2 and 15. Plasma glucose concentrations were affected by QTL on Chr 2, 4, 7, 8, 10, 15, 17, and 18. Comparative genomics narrowed the QTL by 31% to 86%; haplotype analysis was usually able to further narrow it by 80%. We suggest several candidate genes: Gba2 on Chr 4, Irs2 on Chr 8, and Ppargc1b on Chr 18 for TG; A2bp1 on Chr 16 for FFA; and G6pc2 on Chr 2 and Timp3 on Chr 10 for glucose.
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