ArticleProceedings of the National Academy of Sciences of the United States of America2008
Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions.Frontiers in immunology · 2024Review
- Immune Modulation by Antigenic Peptides and Antigenic Peptide Conjugates for Treatment of Multiple Sclerosis.Medical research archives · 2022Article
- A method to induce hen egg lysozyme-specific humoral immune tolerance in mice by pre-exposition with the protein's oligomers.Biochemistry and biophysics reports · 2019Article
- Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Glatiramer acetate attenuates the activation of CD4Scientific reports · 2017Article
- Preclinical development and first-in-human study of ATX-MS-1467 for immunotherapy of MS.Neurology(R) neuroimmunology & neuroinflammation · 2015Article
- Brain protection conferred by long-term administration of 2-(2-benzofuranyl)-2-imidazoline against experimental autoimmune encephalomyelitis.Neurochemical research · 2015Article
- Copolymer-1 promotes neurogenesis and improves functional recovery after acute ischemic stroke in rats.PloS one · 2015Article
- Cannabinoids decrease the th17 inflammatory autoimmune phenotype.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Article
- The role of dendritic cells in the generation of CD4(+) CD25(HI) Foxp3(+) T cells induced by amino acid copolymers.International immunology · 2013Article
- AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice.Gene therapy · 2012Article
- Sweet's syndrome in a neonate with non-B54 types of human leukocyte antigen.World journal of pediatrics : WJP · 2012Article
- Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS).British journal of pharmacology · 2011Review
- The role of cytokines in Guillain-Barré syndrome.Journal of neurology · 2011Review
- Macrophage-specific chemokines induced via innate immunity by amino acid copolymers and their role in EAE.PloS one · 2011Article
- Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Antigenic strength controls the generation of antigen-specific IL-10-secreting T regulatory cells.European journal of immunology · 2010Article
- Inhibition of experimental autoimmune uveitis by amino acid copolymers.Journal of neuroimmunology · 2009Article
- A granulocyte-macrophage colony-stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties.Nature medicine · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
IL-10-secreting regulatory T cell lines specific to glatiramer acetate [poly(Y,E,A,K)n] or poly(Y,F,A,K)n have been established from the enlarged spleen and lymph nodes that result from copolymer treatment of SJL mice in which experimental autoimmune encephalomyelitis was induced by PLP139-151. These CD4+CD25+T cell lines secrete high levels of IL-10 and IL-13 but only small amounts of IL-4 and virtually no TGF-beta, IL-17, IL-6, IFN-gamma, or TNF-alpha. Their phenotypes are particularly characterized by the absence of Foxp3 and the presence of two TNFR family members, CD30 and GITR. The lines proliferated specifically to the immunizing copolymers but were autoantigen-nonspecific, in that the same T cell line could suppress autoimmunity induced by three different autoantigens in SJL mice, i.e., PLP139-151(EAE), MBP85-99 (EAE), and bovine peripheral nerve myelin (experimental autoimmune neuritis), indicating they function by bystander suppression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.