ArticleHeart rhythm2008
A computer modeling tool for comparing novel ICD electrode orientations in children and adults.
Article in Heart rhythm, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 69 citations in OpenAlex.
- Additional coils mitigate elevated defibrillation threshold in right-sided implantable cardioverter defibrillator generator placement: a simulation study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- An in-silico assessment of efficacy of two novel intra-cardiac electrode configurations versus traditional anti-tachycardia pacing therapy for terminating sustained ventricular tachycardia.Computers in biology and medicine · 2021Article
- Computational Model for Therapy Optimization of Wearable Cardioverter Defibrillator: Shockable Rhythm Detection and Optimal Electrotherapy.Frontiers in physiology · 2021Article
- Validating defibrillation simulation in a human-shaped phantom.Heart rhythm · 2020Article
- Implanted pacemaker and cardioverter-defibrillator in a patient with ectopia cordis.HeartRhythm case reports · 2020Article
- Generation of a cohort of whole-torso cardiac models for assessing the utility of a novel computed shock vector efficiency metric for ICD optimisation.Computers in biology and medicine · 2019Article
- Measuring defibrillator surface potentials: The validation of a predictive defibrillation computer model.Computers in biology and medicine · 2018Article
- Effect of ventricular myocardium characteristics on the defibrillation threshold.Technology and health care : official journal of the European Society for Engineering and Medicine · 2018Article
- Highly trabeculated structure of the human endocardium underlies asymmetrical response to low-energy monophasic shocks.Chaos (Woodbury, N.Y.) · 2017Article
- Article
- Bidomain Predictions of Virtual Electrode-Induced Make and Break Excitations around Blood Vessels.Frontiers in bioengineering and biotechnology · 2017Article
- Temporal Dilation of Animal Cardiac Recordings Registered to Human Torso Geometries.Computing in cardiology · 2016Article
- How computer simulations of the human heart can improve anti-arrhythmia therapy.The Journal of physiology · 2016Review
- Initial experience of subcutaneous implantable cardioverter defibrillators in Singapore: a case series and review of the literature.Singapore medical journal · 2015Review
- Generation of Combined-Modality Tetrahedral Meshes.Computing in cardiology · 2015Article
- Primary Prevention of Sudden Cardiac Death in Adults with Transposition of the Great Arteries: A Review of Implantable Cardioverter-Defibrillator Placement.Texas Heart Institute journal · 2015Review
- Images as drivers of progress in cardiac computational modelling.Progress in biophysics and molecular biology · 2014Review
- Virtual 3D heart models to aid pacemaker implantation in children.Future cardiology · 2014Article
- On boundary stimulation and optimal boundary control of the bidomain equations.Mathematical biosciences · 2013Article
- Placement of implantable cardioverter-defibrillators in paediatric and congenital heart defect patients: a pipeline for model generation and simulation prediction of optimal configurations.The Journal of physiology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundUse of implantable cardiac defibrillators (ICDs) in children and patients with congenital heart disease is complicated by body size and anatomy. A variety of creative implantation techniques has been used empirically in these groups on an ad hoc basis.
objectiveTo rationalize ICD placement in special populations, we used subject-specific, image-based finite element models (FEMs) to compare electric fields and expected defibrillation thresholds (DFTs) using standard and novel electrode configurations.
methodsFEMs were created by segmenting normal torso computed tomography scans of subjects ages 2, 10, and 29 years and 1 adult with congenital heart disease into tissue compartments, meshing, and assigning tissue conductivities. The FEMs were modified by interactive placement of ICD electrode models in clinically relevant electrode configurations, and metrics of relative defibrillation safety and efficacy were calculated.
resultsPredicted DFTs for standard transvenous configurations were comparable with published results. Although transvenous systems generally predicted lower DFTs, a variety of extracardiac orientations were also predicted to be comparably effective in children and adults. Significant trend effects on DFTs were associated with body size and electrode length. In many situations, small alterations in electrode placement and patient anatomy resulted in significant variation of predicted DFT. We also show patient-specific use of this technique for optimization of electrode placement.
conclusionImage-based FEMs allow predictive modeling of defibrillation scenarios and predict large changes in DFTs with clinically relevant variations of electrode placement. Extracardiac ICDs are predicted to be effective in both children and adults. This approach may aid both ICD development and patient-specific optimization of electrode placement. Further development and validation are needed for clinical or industrial utilization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.