ArticleImmunology1991
Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes.
Article in Immunology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 166 citations in OpenAlex.
- A longitudinal study of allergy and intestinal helminth infections in semi urban and rural areas of Flores, Indonesia (ImmunoSPIN Study).BMC infectious diseases · 2011Trial
- The role of the IL-9‒NLRP3 axis in insulin resistance and adipose tissue inflammation during diet-induced obesity.Cellular & molecular immunology · 2025Article
- Association of IL-9 Cytokines with Hepatic Injury inBiomolecules · 2024Article
- Article
- Identification of excretory and secretory proteins from Haemonchus contortus inducing a Th9 immune response in goats.Veterinary research · 2022Article
- IL-9-producing T cells: potential players in allergy and cancer.Nature reviews. Immunology · 2021Review
- Article
- ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites.The Journal of experimental medicine · 2019Article
- TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice.PLoS pathogens · 2019Article
- Article
- Epithelial-Cell-Derived Phospholipase ACell host & microbe · 2017Article
- IL-9 and Th9 in parasite immunity.Seminars in immunopathology · 2017Review
- Serglycin proteoglycans limit enteropathy in Trichinella spiralis-infected mice.BMC immunology · 2016Article
- Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis.Infection and immunity · 2013Article
- Protective immunity against Trichinella spiralis infection induced by a multi-epitope vaccine in a murine model.PloS one · 2013Article
- The intraperitoneal inoculation of Lactobacillus casei in mice induces total protection against Trichinella spiralis infection at low challenge doses.Parasitology research · 2011Article
- Transmembrane tumor necrosis factor alpha is required for enteropathy and is sufficient to promote parasite expulsion in gastrointestinal helminth infection.Infection and immunity · 2009Article
- Article
- Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites.International journal for parasitology · 2009Review
- Density-dependent immune responses against the gastrointestinal nematode Strongyloides ratti.International journal for parasitology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Host protective immunity to the intestinal dwelling nematode Trichinella spiralis is mediated by CD4+ mesenteric lymph node (MLN) cells during the course of intestinal infection. The present study has examined the cytokine production by T cells within the MLN of two H-2-compatible strains of mice infected with T. spiralis which differ in the speed at which they expel the parasite from the gut. For both strains of mice, in vitro stimulation of MLN cells with a protective worm antigen preparation resulted in secretion of elevated levels of interleukin-3 (IL-3), IL-4, IL-5 and IL-9 compared to controls. Negligible levels of interferon-gamma (IFN-gamma) were secreted. Furthermore, a similar pattern of cytokine secretion was observed from MLN cells taken from infected mice after in vitro stimulation by T-cell mitogens. No evidence was found for a relationship between quantity of cytokine secreted and the differences in speed of parasite expulsion in the two strains of mice studied. The results support the hypothesis that protective immunity to T. spiralis infection is associated with the activation of Th2-type cells within the MLN in the relative absence of Th1-type cells.
Indexed as
Identifiers
1836201PMC1384613W2107096831What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.