ArticleBiochemical and biophysical research communications2008
Astrin regulates Aurora-A localization.
Article in Biochemical and biophysical research communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Aurora-A V57I (rs1047972) polymorphism and cancer susceptibility: a meta-analysis involving 27,269 subjects.PloS one · 2014Pooled it
- The Aurora B gradient sustains kinetochore stability in anaphase.Cell reports · 2021Article
- Astrin: A Key Player in Mitosis and Cancer.Frontiers in cell and developmental biology · 2020Review
- The Clathrin-dependent Spindle Proteome.Molecular & cellular proteomics : MCP · 2016Article
- Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin.Nature communications · 2016Article
- Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly.Frontiers in oncology · 2015Review
- Microarray comparison of the gene expression profiles in the adult vs. embryonic day 14 rat liver.Biomedical reports · 2014Article
- SPAG5 upregulation predicts poor prognosis in cervical cancer patients and alters sensitivity to taxol treatment via the mTOR signaling pathway.Cell death & disease · 2014Article
- The mitotic spindle protein SPAG5/Astrin connects to the Usher protein network postmitotically.Cilia · 2012Article
- A functional cooperativity between Aurora A kinase and LIM kinase1: implication in the mitotic process.Cell cycle (Georgetown, Tex.) · 2012Article
- Shared and separate functions of polo-like kinases and aurora kinases in cancer.Nature reviews. Cancer · 2010Review
- Aurora B kinase controls the targeting of the Astrin-SKAP complex to bioriented kinetochores.The Journal of cell biology · 2010Article
- Interplay of microtubule dynamics and sliding during bipolar spindle formation in mammalian cells.Current biology : CB · 2009Article
- Low expression of a few genes indicates good prognosis in estrogen receptor positive breast cancer.BMC cancer · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Alterations in the expression and activity of the centrosomal kinase, Aurora-A/STK15, affect genomic stability, disrupt the fidelity of centrosome duplication, and induce cellular transformation. A mitotic spindle-associated protein, astrin/DEEPEST, was identified as an Aurora-A interacting protein by a two-hybrid screen. Astrin and Aurora-A co-express at mitosis and co-localize to mitotic spindles. RNAi-mediated depletion of astrin abolishes the localization of Aurora-A on mitotic spindles and leads to a moderate mitotic cell cycle delay, which resembles the mitotic arrest phenotypes in siAurora-A treated cells. However, depletion of Aurora-A does not affect astrin localization, and co-depletion of both astrin and Aurora-A causes a mitotic arrest phenotype similar to depletion of siAurora-A alone. These results suggest that astrin acts upstream of Aurora-A to regulate its mitotic spindle localization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.