ArticleJournal of proteome research2008
The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions.
Article in Journal of proteome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
173 citing papers in PubMed, 5 syntheses or guidelines pooled it, 440 citations in OpenAlex.
- Circulating miRNAs as liquid biopsy biomarkers for diagnosis in patients with colorectal cancer: a systematic review and meta-analysis.Frontiers in genetics · 2025Pooled it
- Salivary Biomarkers for Diagnosis of Inflammatory Bowel Diseases: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- Proteomic profile of saliva collected directly from ducts: a systematic review.Clinical oral investigations · 2020Pooled it
- Peripheral Blood and Salivary Biomarkers of Blood-Brain Barrier Permeability and Neuronal Damage: Clinical and Applied Concepts.Frontiers in neurology · 2020Pooled it
- Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: a systematic review.Biochemia medica · 2015Pooled it
- System-Level Identification of Heat Stress-Responsive Pathways in Human Saliva.International journal of molecular sciences · 2026Article
- Altered Salivary Microbiome and Increased Immune Markers in Mouth-Breathing Children: Implications for Oral Health.International dental journal · 2026Article
- Salivary Antioxidant and Peroxidase Activity as a Marker of Steroid Hormone Receptor Expression in Breast Cancer.International journal of molecular sciences · 2026Article
- Integrated omics approaches with non-thermal food fortification: pathways to personalized nutrition solutions.Frontiers in nutrition · 2026Review
- Comprehensive GC/MS Profiling of Volatile Organic Compounds in Whole and Glandular Saliva Using MonoTrap Micro-Extraction.Metabolites · 2025Article
- Utilizing saliva for non-invasive detection of exercise-induced myocardial injury with point-of-care cardiac troponin-I.Scientific reports · 2025Article
- Article
- Positive Role of Saliva in the Oral Microbiome.Advances in experimental medicine and biology · 2025Review
- Review
- Salivary Proteomics & Gene Expression Analysis: Applications in Orthodontics and Oral Health Care Research-A Pilot Project.Biomarker insights · 2025Article
- Article
- Morphology of Larger Salivary Glands in Peccaries (Animals : an open access journal from MDPI · 2024Article
- Recombinant neutralizing secretory IgA antibodies for preventing mucosal acquisition and transmission of SARS-CoV-2.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Starch treatment improves the salivary proteome for subject identification purposes.Forensic science, medicine, and pathology · 2024Article
- Impaired oral health: a required companion of bacterial aspiration pneumonia.Frontiers in rehabilitation sciences · 2024Review
113 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
52 authors at 1 institution in 1 country.
Funding
Abstract
Saliva is a body fluid with important functions in oral and general health. A consortium of three research groups catalogued the proteins in human saliva collected as the ductal secretions: 1166 identifications--914 in parotid and 917 in submandibular/sublingual saliva--were made. The results showed that a high proportion of proteins that are found in plasma and/or tears are also present in saliva along with unique components. The proteins identified are involved in numerous molecular processes ranging from structural functions to enzymatic/catalytic activities. As expected, the majority mapped to the extracellular and secretory compartments. An immunoblot approach was used to validate the presence in saliva of a subset of the proteins identified by mass spectrometric approaches. These experiments focused on novel constituents and proteins for which the peptide evidence was relatively weak. Ultimately, information derived from the work reported here and related published studies can be used to translate blood-based clinical laboratory tests into a format that utilizes saliva. Additionally, a catalogue of the salivary proteome of healthy individuals allows future analyses of salivary samples from individuals with oral and systemic diseases, with the goal of identifying biomarkers with diagnostic and/or prognostic value for these conditions; another possibility is the discovery of therapeutic targets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.