ArticleJournal of medical virology2008
Detection of a broad range of human adenoviruses in respiratory tract samples using a sensitive multiplex real-time PCR assay.
Article in Journal of medical virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 85 citations in OpenAlex.
- Trial
- Adenovirus Genotypes Associated With Severe Acute Respiratory Infections Outbreak in Children, in Antioquia, Colombia, 2022-2023.The Pediatric infectious disease journal · 2026Article
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- A Novel Multiplex LAMP Assay for the Detection of Respiratory Human Adenoviruses.International journal of molecular sciences · 2024Article
- Significantly Longer Shedding of Norovirus Compared to Rotavirus and Adenovirus in Children with Acute Gastroenteritis.Viruses · 2023Article
- Changes in virus detection in hospitalized children before and after the severe acute respiratory syndrome coronavirus 2 pandemic.Influenza and other respiratory viruses · 2022Article
- Respiratory syncytial virus among children hospitalized with severe acute respiratory infection in Kashmir, a temperate region in northern India.Journal of global health · 2022Observational
- Epidemiological and clinical characteristics of infections with seasonal human coronavirus and respiratory syncytial virus in hospitalized children immediately before the coronavirus disease 2019 pandemic.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2022Article
- Development of a Rapid Immuno-Based Screening Assay for the Detection of Adenovirus in Eye Infections.ACS omega · 2022Article
- Clinical manifestations and outcome of viral acute lower respiratory infection in hospitalised children in Myanmar.BMC infectious diseases · 2022Article
- Microfluidic sample preparation for respiratory virus detection: A review.Biomicrofluidics · 2021Review
- Comparison of Three Adenovirus Quantitative PCR Assays with ATCC Reference Strains and Clinical Samples.Journal of clinical microbiology · 2019Article
- Repositioning salicylanilide anthelmintic drugs to treat adenovirus infections.Scientific reports · 2019Article
- Prematurity, a significant predictor for worse outcome in viral bronchiolitis: a comparative study in infancy.The Journal of the Egyptian Public Health Association · 2019Article
- Respiratory viruses in returning Hajj & Umrah pilgrims with acute respiratory illness in 2014-2015.The Indian journal of medical research · 2018Article
- Clinical and molecular features of adenovirus type 2, 3, and 7 infections in children in an outbreak in Taiwan, 2011.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2017Article
- A comprehensive method for amplicon-based and metagenomic characterization of viruses, bacteria, and eukaryotes in freshwater samples.Microbiome · 2016Article
- Article
- Respiratory Viral Detections During Symptomatic and Asymptomatic Periods in Young Andean Children.The Pediatric infectious disease journal · 2015Article
- Detection of respiratory viruses in gargle specimens of healthy children.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human adenoviruses (hAdVs) are associated with acute respiratory tract infections in pediatric populations and have been identified as a cause of outbreaks in institutional settings. Rapid diagnosis of hAdV infection is critical for appropriate and timely management. This study reports the design and validation of a sensitive and specific multiplex real-time PCR for the detection of a broad range of hAdV serotypes in respiratory samples. The assay targets the conserved region of the hAdV hexon gene and utilizes hydrolysis probes for the detection of amplified products. The assay was evaluated using retrospectively (n = 864) and prospectively (n = 11,451) collected samples from November 2005 to July 2006. Seasonality studies and analysis of outbreaks was conducted over a 2-year period from January 2005 to December 2006 (n = 33,067 samples). The assay gave a hAdV positive rate of 7.1% (n = 811) for specimens tested prospectively and was able to detect a broad range of hAdV serotypes with good sensitivity and specificity. A high rate of co-infection was noted (21.7%). Adenovirus infections were more prevalent in the young with a median age of 24 months for positive patients. Sequence analysis of hAdV positives showed that serotype 7 was the most prevalent followed by serotypes 2 and 3. Association of hAdVs with respiratory outbreaks was low at 2.3% (6 of 266 outbreaks tested) and no seasonal variation was observed for hAdV infections during the 2-year study period. This assay can improve the detection of hAdVs in respiratory samples and can be used to provide valuable epidemiological information.
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