ArticleMolecular biology reports2009
Sequence structure and expression pattern of a novel anionic defensin-like gene from silkworm (Bombyx mori).
Article in Molecular biology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Specific Expression of Antimicrobial Peptides from the Black Soldier Fly in the Midgut of Silkworms (Insects · 2023Article
- In silico characterization of cysteine-stabilized αβ defensins from neglected unicellular microeukaryotes.BMC microbiology · 2023Article
- Pathogenesis and defense mechanism while Beauveria bassiana JEF-410 infects poultry red mite, Dermanyssus gallinae.PloS one · 2023Article
- The Functions of β-Defensin in Flounder (Biology · 2021Article
- Blattella germanica displays a large arsenal of antimicrobial peptide genes.Scientific reports · 2020Article
- Effects of Quercetin on the Growth and Expression of Immune-Pathway-Related Genes in Silkworm (Lepidoptera: Bombycidae).Journal of insect science (Online) · 2020Article
- A Toll-Spätzle Pathway in the Immune Response ofInsects · 2020Article
- Antifungal Activity of Anionic Defense Peptides: Insight into the Action ofInternational journal of molecular sciences · 2020Article
- Antimicrobial peptides fromRSC advances · 2019Review
- Antimicrobial peptide gene BdPho responds to peptidoglycan infection and mating stimulation in oriental fruit fly, Bactrocera dorsalis (Hendel).AMB Express · 2018Article
- Structure-Activity Relationships of Insect Defensins.Frontiers in chemistry · 2017Review
- Article
- Article
- Identification, phylogenetic analysis and expression profile of an anionic insect defensin gene, with antibacterial activity, from bacterial-challenged cotton leafworm, Spodoptera littoralis.BMC molecular biology · 2011Article
- Molecular cloning and characterization of lactate dehydrogenase gene 1 in the silkworm, Bombyx mori.Molecular biology reports · 2011Article
- Transcriptional regulation of the gene for prothoracicotropic hormone in the silkworm, Bombyx mori.Molecular biology reports · 2011Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A defensin-like gene, BmdefA, was rediscovered in the silkworm genome and expressed sequence tags databases. The open reading frame of BmdefA encodes a prepropeptide consisting of a 22-residue signal peptide, a 34-residue propeptide, and a 36-residue mature peptide with a molecular mass of 4.0 kDa. The mature peptide possesses the characteristic six-cysteine motif of insect defensins, and its predicted isoelectric point is 4.12, indicating it is a novel anionic defensin. An intron is present in BmdefA and several cis-regulatory elements are in the regulating region. It is transcribed constitutively at a high level in the hemocyte, silk gland, head, and ovary of the silkworm larvae, and in the fat body of early-stage pupae and moth. BmdefA is also strongly induced by immune challenge. These results suggest that BmdefA plays an important role in both immunity and metamorphosis.
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