ArticleBehavior genetics2008
The nature of nurture: a genomewide association scan for family chaos.
Article in Behavior genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Patterns and predictors of adolescent life change during the COVID-19 pandemic: a person-centered approach.Current psychology (New Brunswick, N.J.) · 2023Article
- Measuring CHAOS? Evaluating the short-form Confusion, Hubbub And Order Scale.Collabra. Psychology · 2023Article
- ALS/FTD: Evolution, Aging, and Cellular Metabolic Exhaustion.Frontiers in neurology · 2022Article
- Widespread covariation of early environmental exposures and trait-associated polygenic variation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Deciphering Genome Environment Wide Interactions Using Exposed Subjects Only.Genetic epidemiology · 2015Article
- Whole-miRNome profiling identifies prognostic serum miRNAs in esophageal adenocarcinoma: the influence of Helicobacter pylori infection status.Carcinogenesis · 2015Article
- Genotype-environment correlation in the era of DNA.Behavior genetics · 2014Article
- Utility of the pooling approach as applied to whole genome association scans with high-density Affymetrix microarrays.BMC research notes · 2010Article
- Quantitative genetics in the era of molecular genetics: learning abilities and disabilities as an example.Journal of the American Academy of Child and Adolescent Psychiatry · 2010Review
- Article
- Human difference in the genomic era: Facilitating a socially responsible dialogue.BMC medical genomics · 2010Article
- A nonword repetition task for speakers with misarticulations: the Syllable Repetition Task (SRT).Journal of speech, language, and hearing research : JSLHR · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Widely used measures of the environment, especially the family environment of children, show genetic influence in dozens of twin and adoption studies. This phenomenon is known as gene-environment correlation in which genetically driven influences of individuals affect their environments. We conducted the first genome-wide association (GWA) analysis of an environmental measure. We used a measure called CHAOS which assesses 'environmental confusion' in the home, a measure that is more strongly associated with cognitive development in childhood than any other environmental measure. CHAOS was assessed by parental report when the children were 3 years and again when the children were 4 years; a composite CHAOS measure was constructed across the 2 years. We screened 490,041 autosomal single-nucleotide polymorphisms (SNPs) in a two-stage design in which children in low chaos families (N = 469) versus high chaos families (N = 369) from 3,000 families of 4-year-old twins were screened in Stage 1 using pooled DNA. In Stage 2, following SNP quality control procedures, 41 nominated SNPs were tested for association with family chaos by individual genotyping an independent representative sample of 3,529. Despite having 99% power to detect associations that account for more than 0.5% of the variance, none of the 41 nominated SNPs met conservative criteria for replication. Similar to GWA analyses of other complex traits, it is likely that most of the heritable variation in environmental measures such as family chaos is due to many genes of very small effect size.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.