ArticleTherapeutics and clinical risk management2005
Clinical implications of changes in hepatic drug metabolism in older people.
Article in Therapeutics and clinical risk management, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Severe numbness of the mouth and tongue induced by piperacillin/tazobactam: a rare case report.Future science OA · 2026Article
- Opioids to Treat Chronic Pain in the Older Adult: A Clinical Consensus to Guarantee Safety and Avoid Adverse Events.Drugs & aging · 2026Review
- Molecular Aspects of Geriatric Pharmacotherapy.Cells · 2025Review
- Caffeine in Aging Brains: Cognitive Enhancement, Neurodegeneration, and Emerging Concerns About Addiction.International journal of environmental research and public health · 2025Review
- Safety evaluation of cinacalcet: Signal mining and analysis of adverse events based on the FAERS database.PloS one · 2025Article
- Considerations for Anesthesia in Older Adults with Cannabis Use.Drugs & aging · 2024Review
- Long-Term Pharmacokinetic Follow-Up of Abiraterone Acetate in Patients with Metastatic Castration-Resistant Prostate Cancer.International journal of molecular sciences · 2024Article
- Turmeric-induced Liver Injury.Journal of community hospital internal medicine perspectives · 2024Article
- Safety Profile of Medicines Used for the Treatment of Drug-Resistant Tuberculosis: A Descriptive Study Based on the WHO Database (VigiBaseAntibiotics (Basel, Switzerland) · 2023Article
- Everolimus Exposure and Early Metabolic Response as Predictors of Treatment Outcomes in Breast Cancer Patients Treated with Everolimus and Exemestane.Targeted oncology · 2018Article
- The aging kidney and the nephrotoxic effects of mercury.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- A Comprehensive Look at Polypharmacy and Medication Screening Tools for the Older Cancer Patient.The oncologist · 2016Review
- Age-Related Changes in Hepatic Function: An Update on Implications for Drug Therapy.Drugs & aging · 2015Review
- The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats.Experimental gerontology · 2015Article
- Pharmacokinetics of antidepressants in patients with hepatic impairment.Clinical pharmacokinetics · 2014Review
- A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening.Experimental biology and medicine (Maywood, N.J.) · 2014Review
- Effect of age and gender on pharmacokinetics and pharmacodynamics of a single ticagrelor dose in healthy individuals.European journal of clinical pharmacology · 2012Article
- Prescribing in care homes: the role of the geriatrician.Therapeutic advances in chronic disease · 2011Article
- Age-related changes in the hepatic pharmacology and toxicology of paracetamol.Current gerontology and geriatrics research · 2011Article
- Drug-induced liver injury in older adults.Therapeutic advances in drug safety · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prescribing for older people is challenging because of the paucity of clinical trial evidence of therapeutic benefit in this population and the presence of evidence that older people are at increased risk of adverse drug reactions. The outcomes of pharmacotherapies in older people depend on age-related changes in both pharmacokinetics and pharmacodynamics. Of the pharmacokinetic changes, those in hepatic metabolism are the most significant. Recent advances in biogerontology have improved our understanding of changes that occur in hepatic pharmacokinetics in older people. Knowledge of age-related changes in hepatic metabolism can guide prescribing and help reduce the risk-benefit ratio of using medications in older people.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.