ArticleJournal of acquired immune deficiency syndromes (1999)2008
Host CCL3L1 gene copy number in relation to HIV-1-specific CD4+ and CD8+ T-cell responses and viral load in South African women.
Article in Journal of acquired immune deficiency syndromes (1999), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pooled it
- Malignant clonal evolution drives multiple myeloma cellular ecological diversity and microenvironment reprogramming.Molecular cancer · 2022Article
- Common Variation inOpen forum infectious diseases · 2018Article
- Conserved HIV-1 Gag p24 Epitopes Elicit Cellular Immune Responses That Impact Disease Outcome.AIDS research and human retroviruses · 2017Article
- Influence of intragenic CCL3 haplotypes and CCL3L copy number in HIV-1 infection in a sub-Saharan African population.Genes and immunity · 2013Article
- CCL3L1 gene copy number in individuals with and without HIV-associated neurocognitive disorder.Current biomarker findings · 2012Article
- Natural killer cells that respond to human immunodeficiency virus type 1 (HIV‐1) peptides are associated with control of HIV‐1 infection.The Journal of infectious diseases · 2010Article
- Mendelian randomization: potential use of genetics to enable causal inferences regarding HIV-associated biomarkers and outcomes.Current opinion in HIV and AIDS · 2010Review
- Copy number variation in chemokine superfamily: the complex scene of CCL3L-CCL4L genes in health and disease.Clinical and experimental immunology · 2010Review
- Variations in CCL3L gene cluster sequence and non-specific gene copy numbers.BMC research notes · 2010Article
- CCL3L1 copy number is a strong genetic determinant of HIV seropositivity in Caucasian intravenous drug users.The Journal of infectious diseases · 2010Article
- A whole genome association study of mother-to-child transmission of HIV in Malawi.Genome medicine · 2010Article
- Gene copy number: learning to count past two.Nature medicine · 2009Article
- Single-dose nevirapine exposure affects T cell response and cytokine levels in HIV type 1-infected women.AIDS research and human retroviruses · 2009Article
- Cutting Edge: Unusual NK cell responses to HIV-1 peptides are associated with protection against maternal-infant transmission of HIV-1.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Identification of human immunodeficiency virus-1 specific CD8+ and CD4+ T cell responses in perinatally-infected infants and their mothers.AIDS (London, England) · 2009Article
- Genetic determinants of HIV-1 infection and progression to AIDS: susceptibility to HIV infection.Tissue antigens · 2009Review
- Combinatorial content of CCL3L and CCL4L gene copy numbers influence HIV-AIDS susceptibility in Ukrainian children.AIDS (London, England) · 2009Article
- CCL3L Copy number variation and the co-evolution of primate and viral genomes.PLoS genetics · 2009Article
- Copy number variation of CCL3-like genes affects rate of progression to simian-AIDS in Rhesus Macaques (Macaca mulatta).PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
HIV-specific T-cell responses play an important role in control of infection. Because CCL3 has immune modulatory and antiviral activities, we hypothesized that host CCL3 genotype (CCL3L1 gene duplications) would influence the development of effective HIV-specific immune responses. Copy numbers of CCL3L1 were determined for 71 HIV-infected women, and HIV-specific CD4 and CD8 T-cell responses to overlapping peptide pools spanning the HIV-1 subtype C genome were simultaneously measured by an interferon-gamma and interleukin-2 whole-blood flow cytometric assay. Host CCL3L1 copy number correlated negatively with viral load (r=-0.239, P=0.045), as did magnitudes of Gag CD4 (r=-0.362, P=0.002) and CD8 (r=-0.261, P=0.028) T-cell responses. Patients with a Gag CD4 response (P=0.002) or dominant Gag CD8 (P=0.006) response had significantly lower viral loads than those whose dominant response targeted another region of the genome, whereas a dominant Nef-specific CD8 T-cell response was associated with higher HIV viral load. CCL3L1 copy number greater than or equal to the population median of 5 was significantly associated with increased magnitude of CD4 Gag responses (P=0.017), and women who had CD4 and CD8 Gag-specific responses had significantly lower viral loads (P=0.004) and higher CCL3L1 copy number (P=0.015) than those women with only CD8 Gag-specific responses.
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Registered trials
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