ArticlePlant physiology2008
Mild reductions in mitochondrial citrate synthase activity result in a compromised nitrate assimilation and reduced leaf pigmentation but have no effect on photosynthetic performance or growth.
Article in Plant physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 96 citations in OpenAlex.
- Citric acid alters Arabidopsis root morphology and development through ROS-dependent and ROS-independent mechanisms.Plant physiology · 2026Article
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- GWAS on multiple traits identifies mitochondrial ACONITASE3 as important for acclimation to submergence stress.Plant physiology · 2022Article
- A multi-organ metabolic model of tomato predicts plant responses to nutritional and genetic perturbations.Plant physiology · 2022Article
- The versatility of plant organic acid metabolism in leaves is underpinned by mitochondrial malate-citrate exchange.The Plant cell · 2021Article
- Comparative genomic analysis of the tricarboxylic acid cycle members in four Solanaceae vegetable crops and expression pattern analysis in Solanum tuberosum.BMC genomics · 2021Article
- Downregulation of the E2 Subunit of 2-Oxoglutarate Dehydrogenase Modulates Plant Growth by Impacting Carbon-Nitrogen Metabolism in Arabidopsis thaliana.Plant & cell physiology · 2021Article
- The mitochondrial pyruvate carrier (MPC) complex mediates one of three pyruvate-supplying pathways that sustain Arabidopsis respiratory metabolism.The Plant cell · 2021Article
- Metabolite Profiling inMetabolites · 2021Article
- Identification and characterization of the TCA cycle genes in maize.BMC plant biology · 2019Article
- The Arabidopsis EPlant molecular biology · 2019Article
- The rice zebra3 (z3) mutation disrupts citrate distribution and produces transverse dark-green/green variegation in mature leaves.Rice (New York, N.Y.) · 2018Article
- Modifications in Organic Acid Profiles During Fruit Development and Ripening: Correlation or Causation?Frontiers in plant science · 2018Review
- Disruptions in valine degradation affect seed development and germination in Arabidopsis.The Plant journal : for cell and molecular biology · 2017Article
- Bile Acid Sodium Symporter BASS6 Can Transport Glycolate and Is Involved in Photorespiratory Metabolism inThe Plant cell · 2017Article
- GLYCOLATE OXIDASE3, a Glycolate Oxidase Homolog of Yeast l-Lactate Cytochrome c Oxidoreductase, Supports l-Lactate Oxidation in Roots of Arabidopsis.Plant physiology · 2015Article
- Performance Assessment of the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Method for Rapid Detection of Susceptibility to Ethambutol and Molecular Prediction of Extensively Drug-resistant Tuberculosis in Clinical Isolates of Mycobacterium tuberculosis.The West Indian medical journal · 2015Article
- Mitochondrial Dihydrolipoyl Dehydrogenase Activity Shapes Photosynthesis and Photorespiration of Arabidopsis thaliana.The Plant cell · 2015Article
- Evolution and functional implications of the tricarboxylic acid cycle as revealed by phylogenetic analysis.Genome biology and evolution · 2014Article
- On the role of plant mitochondrial metabolism and its impact on photosynthesis in both optimal and sub-optimal growth conditions.Photosynthesis research · 2014Review
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
Transgenic tomato (Solanum lycopersicum) plants, expressing a fragment of the mitochondrial citrate synthase gene in the antisense orientation and exhibiting mild reductions in the total cellular activity of this enzyme, displayed essentially no visible phenotypic alteration from the wild type. A more detailed physiological characterization, however, revealed that although these plants were characterized by relatively few changes in photosynthetic parameters they displayed a decreased relative flux through the tricarboxylic acid cycle and an increased rate of respiration. Furthermore, biochemical analyses revealed that the transformants exhibited considerably altered metabolism, being characterized by slight decreases in the levels of organic acids of the tricarboxylic acid cycle, photosynthetic pigments, and in a single line in protein content but increases in the levels of nitrate, several amino acids, and starch. We additionally determined the maximal catalytic activities of a wide range of enzymes of primary metabolism, performed targeted quantitative PCR analysis on all three isoforms of citrate synthase, and conducted a broader transcript profiling using the TOM1 microarray. Results from these studies confirmed that if the lines were somewhat impaired in nitrate assimilation, they were not severely affected by this, suggesting the presence of strategies by which metabolism is reprogrammed to compensate for this deficiency. The results are discussed in the context of carbon-nitrogen interaction and interorganellar coordination of metabolism.
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