ArticleApplied and environmental microbiology2008
Collateral effects of antibiotics: carbadox and metronidazole induce VSH-1 and facilitate gene transfer among Brachyspira hyodysenteriae strains.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Perturbations shift the composition of bacterial DNA carried by virus-like particles in the murine gut microbiome.bioRxiv : the preprint server for biology · 2026Article
- Carbadox, a veterinary growth promoter exhibits anticlostridial activity through induction of oxidative stress in Clostridioides difficile.Gut pathogens · 2026Article
- DNA Gyrase Inhibitors Increase the Frequency of Bacteriophage-like RcGTA-Mediated Gene Transfer inGenes · 2022Article
- Formal recognition and classification of gene transfer agents as viriforms.Virus evolution · 2022Article
- Fitness benefits to bacteria of carrying prophages and prophage-encoded antibiotic-resistance genes peak in different environments.Evolution; international journal of organic evolution · 2021Article
- Gene Transfer Agents in Symbiotic Microbes.Results and problems in cell differentiation · 2020Review
- Antimicrobial Resistance inMicrobiology spectrum · 2020Review
- Bacteriophages as New Human Viral Pathogens.Microorganisms · 2018Article
- The In-Feed Antibiotic Carbadox Induces Phage Gene Transcription in the Swine Gut Microbiome.mBio · 2017Article
- Identification of constraints influencing the bacterial genomes evolution in the PVC super-phylum.BMC evolutionary biology · 2017Article
- Mechanisms of Antibacterial Action of Quinoxaline 1,4-di-Frontiers in microbiology · 2016Article
- Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer.Frontiers in microbiology · 2016Review
- The Exposed Proteomes of Brachyspira hyodysenteriae and B. pilosicoli.Frontiers in microbiology · 2016Article
- Article
- Carbadox has both temporary and lasting effects on the swine gut microbiota.Frontiers in microbiology · 2014Article
- The agricultural antibiotic carbadox induces phage-mediated gene transfer in Salmonella.Frontiers in microbiology · 2014Article
- Gene transfer agents: phage-like elements of genetic exchange.Nature reviews. Microbiology · 2012Review
- Article
- Genetics of Borrelia burgdorferi.Annual review of genetics · 2012Review
- Horizontal gene exchange in environmental microbiota.Frontiers in microbiology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brachyspira hyodysenteriae is an anaerobic spirochete and the etiologic agent of swine dysentery. The genome of this spirochete contains a mitomycin C-inducible, prophage-like gene transfer agent designated VSH-1. VSH-1 particles package random 7.5-kb fragments of the B. hyodysenteriae genome and transfer genes between B. hyodysenteriae cells. The chemicals and conditions inducing VSH-1 production are largely unknown. Antibiotics used in swine management and stressors inducing traditional prophages might induce VSH-1 and thereby stimulate lateral gene transfer between B. hyodysenteriae cells. In these studies, VSH-1 induction was initially detected by a quantitative real-time reverse transcriptase PCR assay evaluating increased transcription of hvp38 (VSH-1 head protein gene). VSH-1 induction was confirmed by detecting VSH-1-associated 7.5-kb DNA and VSH-1 particles in B. hyodysenteriae cultures. Nine antibiotics (chlortetracycline, lincomycin, tylosin, tiamulin, virginiamycin, ampicillin, ceftriaxone, vancomycin, and florfenicol) at concentrations affecting B. hyodysenteriae growth did not induce VSH-1 production. By contrast, VSH-1 was detected in B. hyodysenteriae cultures treated with mitomycin C (10 microg/ml), carbadox (0.5 microg/ml), metronidazole (0.5 microg/ml), and H(2)O(2) (300 microM). Carbadox- and metronidazole-induced VSH-1 particles transmitted tylosin and chloramphenicol resistance determinants between B. hyodysenteriae strains. The results of these studies suggest that certain antibiotics may induce the production of prophage or prophage-like elements by intestinal bacteria and thereby impact intestinal microbial ecology.
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