ArticleEpilepsy & behavior : E&B2008
Amygdala volume and psychopathology in childhood complex partial seizures.
Article in Epilepsy & behavior : E&B, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Prediction of Post Traumatic Epilepsy Using MR-Based Imaging Markers.Human brain mapping · 2024Article
- Neuroanatomic Markers of Posttraumatic Epilepsy Based on MR Imaging and Machine Learning.AJNR. American journal of neuroradiology · 2022Article
- Disruptions in cortico-subcortical covariance networks associated with anxiety in new-onset childhood epilepsy.NeuroImage. Clinical · 2016Article
- Quantifying the deficit-imaging neurobehavioural impairment in childhood epilepsy.Quantitative imaging in medicine and surgery · 2015Review
- Article
- Neuroimaging of frontal-limbic dysfunction in schizophrenia and epilepsy-related psychosis: toward a convergent neurobiology.Epilepsy & behavior : E&B · 2012Review
- Deformation-based morphometry of prospective neurodevelopmental changes in new onset paediatric epilepsy.Brain : a journal of neurology · 2011Article
- Brain development in children with new onset epilepsy: a prospective controlled cohort investigation.Epilepsia · 2010Article
- The emerging architecture of neuropsychological impairment in epilepsy.Neurologic clinics · 2009Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe purpose of this study was to compare amygdala volume in children with cryptogenic epilepsy who have complex partial seizures (CPS) with that of age- and gender-matched normal children. The relationship of amygdala volume to seizure variables and presence of psychopathology was also examined in these patients.
methodsTwenty-eight children with cryptogenic epilepsy, all of whom had CPS, and gender-matched normal children, all aged 6-16 years, underwent magnetic resonance imaging (MRI) at 1.5T. Tissue was segmented, and total brain volume and amygdala volumes obtained from manual tracings were computed.
resultsThere were no significant differences in amygdala volume between the CPS and normal groups. Within the CPS group, the children with an affective/anxiety disorder had significantly larger left amygdala volumes, as well as greater amygdala asymmetry, compared with those with no psychopathology. Exploring the association between seizure variables and amygdala volume yielded no significant predictors.
conclusionsIn pediatric CPS, left amygdala involvement may reflect effects of the neuropathology underlying comorbid affective or anxiety disorders on amygdala development rather than effects of ongoing seizures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.