Evidence map›Paper›PMID 18359186›Full record

ArticleBrain, behavior, and immunity2008

Effect of mindfulness based stress reduction on immune function, quality of life and coping in women newly diagnosed with early stage breast cancer.

Linda Witek-Janusek, Kevin Albuquerque, Karen Rambo Chroniak, Christopher Chroniak, Ramon Durazo-Arvizu, Herbert L Mathews

Registry-linked trialOpen access · greenAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03652935 (Mindfulness Based Stress Reduction for Psycho-Immune Dysregulation), which is not on this map. Cited by 163 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 15 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03652935 nacompletednot on this map

Mindfulness Based Stress Reduction for Psycho-Immune Dysregulation

TypeinterventionalSponsorLoyola UniversityRan2008 to 2013Enrolled192ConditionsBreast CancerArmsMindfulness Based Stress Reduction, Health Education Series
3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 15 syntheses or guidelines pooled it, 502 citations in OpenAlex.

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  8. Guideline
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  13. Meditation for adults with haematological malignancies.The Cochrane database of systematic reviews · 2016
    Pooled it
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  15. Breast cancer and coping among women of color: a systematic review of the literature.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014
    Pooled it
  16. Mindfulness Meditation Reduces Stress and Hospital Stay in Gastrointestinal Tumor Patients During Perioperative Period.Medical science monitor : international medical journal of experimental and clinical research · 2024
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103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Linda Witek-JanusekNiehoff School of Nursing, Loyola University of Chicago, Maguire Center, Room 2840, 2160 South First Avenue, Maywood, IL 60153, USA. ljanuse@luc.edu
Kevin Albuquerque
Karen Rambo Chroniak
Christopher Chroniak
Ramon Durazo-Arvizu
Herbert L Mathews
Loyola University Chicago · USUniversity of Chicago · USChicago Institute for Psychoanalysis · USInsight (China) · CN

Funding

MBSR for Stress-Related Immune Dysregulation in CancerR21CA098643 · NCI · LOYOLA UNIVERSITY OF CHICAGO · PI JANUSEK, LINDA · 2003 to 2004
$444k
NCI NIH HHS R21 CA098643NCI NIH HHS R21-CA-9864
6 · The paper itself

Abstract

This investigation used a non-randomized controlled design to evaluate the effect and feasibility of a mindfulness based stress reduction (MBSR) program on immune function, quality of life (QOL), and coping in women recently diagnosed with breast cancer. Early stage breast cancer patients, who did not receive chemotherapy, self-selected into an 8-week MBSR program or into an assessment only, control group. Outcomes were evaluated over time. The first assessment was at least 10 days after surgery and prior to adjuvant therapy, as well as before the MBSR start-up. Further assessments were mid-MBSR, at completion of MBSR, and at 4-week post-MBSR completion. Women with breast cancer enrolled in the control group (Non-MBSR) were assessed at similar times. At the first assessment (i.e., before MBSR start), reductions in peripheral blood mononuclear cell NK cell activity (NKCA) and IFN-gamma production with increases in IL-4, IL-6, and IL-10 production and plasma cortisol levels were observed for both the MBSR and Non-MBSR groups of breast cancer patients. Over time women in the MBSR group re-established their NKCA and cytokine production levels. In contrast, breast cancer patients in the Non-MBSR group exhibited continued reductions in NKCA and IFN-gamma production with increased IL-4, IL-6, and IL-10 production. Moreover, women enrolled in the MBSR program had reduced cortisol levels, improved QOL, and increased coping effectiveness compared to the Non-MBSR group. In summary, MBSR is a program that is feasible for women recently diagnosed with early stage breast cancer and the results provide preliminary evidence for beneficial effects of MBSR; on immune function, QOL, and coping.

Indexed as

Adaptation, PsychologicalAdultAgedBreast NeoplasmsCytokinesFemaleFollow-Up StudiesHealth PromotionHumansHydrocortisoneImmunityKiller Cells, Lymphokine-ActivatedMeditationMiddle AgedMind-Body Relations, MetaphysicalNeoplasm StagingCytokinesHydrocortisone

Identifiers

PMID18359186
PMCPMC2586059
OpenAlexW2084135738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.