ArticleBiological psychiatry2008
Promoter variant in the GRK3 gene associated with bipolar disorder alters gene expression.
Article in Biological psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Neuroactive Kynurenines as Pharmacological Targets: New Experimental Tools and Exciting Therapeutic Opportunities.Pharmacological reviews · 2024Review
- Alterations in blood proteins in the prodromal stage of bipolar II disorders.Scientific reports · 2022Article
- GRK3 deficiency elicits brain immune activation and psychosis.Molecular psychiatry · 2021Article
- G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 inThe Journal of biological chemistry · 2017Article
- Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer.Disease markers · 2017Article
- Targeting G protein coupled receptor-related pathways as emerging molecular therapies.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2015Review
- Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders.Human molecular genetics · 2014Article
- Genetic basis of olfactory cognition: extremely high level of DNA sequence polymorphism in promoter regions of the human olfactory receptor genes revealed using the 1000 Genomes Project dataset.Frontiers in psychology · 2014Article
- Implications and limitations of cellular reprogramming for psychiatric drug development.Experimental & molecular medicine · 2013Review
- G protein-coupled receptor kinases: more than just kinases and not only for GPCRs.Pharmacology & therapeutics · 2012Review
- Genome-wide association study of recurrent early-onset major depressive disorder.Molecular psychiatry · 2011Article
- Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.Molecular psychiatry · 2011Article
- A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder.BMC systems biology · 2010Article
- The genetics of major depression: moving beyond the monoamine hypothesis.The Psychiatric clinics of North America · 2010Review
- Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients.Journal of psychiatric research · 2010Article
- The transcription factor SP4 is reduced in postmortem cerebellum of bipolar disorder subjects: control by depolarization and lithium.Bipolar disordersArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe have previously reported a single nucleotide polymorphism (P-5, G-384A) in the proximal promoter of the gene for G protein receptor kinase 3 (GRK3) that was associated with bipolar disorder in two independent samples. In this study, we examined whether the G-384A variant has a functional effect on GRK3 transcription.
methodsElectrophoretic mobility shift assays were conducted using nuclear extracts from both Hela cells and adult mouse cortex. Transcriptional function was also examined using a dual luciferase reporter system transfected into in vitro human neuroblastoma cells and cultured mouse cortical neurons.
resultsThe G-384A variant abolished or reduced the formation of DNA-protein complexes using nuclear extract from both HeLa cells and adult mouse cortical neuron cells. However, gene expression was significantly enhanced by G-384A in both in vitro human neuroblastoma cells and cultured mouse cortical neurons.
conclusionsThese data suggest that the G-384A SNP in the promoter of human GRK3 gene represents an important functional variant. The G-384A variant may alter binding of Sp1/Sp4 transcription factors resulting in an increase in gene transcription and an increase in vulnerability to bipolar disorder.
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