ArticleBiochemical pharmacology2008
Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanism.
Article in Biochemical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- The ubiquitin-proteasome system and proteostasis in the cochlea and sensorineural hearing disorders.Molecular biomedicine · 2026Review
- An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways.Biomedicines · 2023Review
- The decreased expression of IKBKE in systemic lupus erythematosus.Clinical rheumatology · 2020Article
- Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- HILAQ: A Novel Strategy for Newly Synthesized Protein Quantification.Journal of proteome research · 2017Article
- Lack of neuroprotective effect of celastrol under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson's disease.Neurotoxicity research · 2014Article
- The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.Antioxidants & redox signaling · 2013Review
- Quiescent fibroblasts are protected from proteasome inhibition-mediated toxicity.Molecular biology of the cell · 2012Article
- Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression.Cell death and differentiation · 2012Article
- Hesperidin, a flavone glycoside, as mediator of neuronal survival.Neurochemical research · 2011Article
- Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin.Genes & nutrition · 2009Article
- Role of oxidative stress in geldanamycin-induced cytotoxicity and disruption of Hsp90 signaling complex.Free radical biology & medicine · 2009Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The role of the proteasome in neurodegenerative diseases is controversial. On the one hand, there is evidence that a dysfunction of proteasome activity can lead to neurodegeneration but there is also data showing that proteasome inhibition can protect nerve cells from a variety of insults. In an attempt to clarify this issue, we studied the effects of four different proteasome inhibitors in a well characterized model of oxidative stress-induced nerve cell death. Consistent with the hypothesis that proteasome inhibition can be neuroprotective, we found that low concentrations of proteasome inhibitors were able to protect nerve cells from oxidative stress-induced death. Surprisingly, the neuroprotective effects of the proteasome inhibitors appeared to be at least partially mediated by the induction of NF-kappaB since protection was significantly reduced in cells expressing a specific NF-kappaB repressor. The activation of NF-kB by proteasome inhibitors was mediated by IkappaB alpha and IKK and was blocked by antioxidants and inhibitors of mitochondrial reactive oxygen species production. These data suggest that low concentrations of proteasome inhibitors induce a moderate level of mitochondrial oxidative stress which results in the activation of neuroprotective pathways.
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