ArticleThe Journal of nutrition2008
Zinc deficiency alters DNA damage response genes in normal human prostate epithelial cells.
Article in The Journal of nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- The effects of zinc on radiation-induced dysgeusia: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Pooled it
- Zinc supplementation reduced DNA breaks in Ethiopian women.Nutrition research (New York, N.Y.) · 2015Trial
- The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications.Annals of medicine · 2026Review
- Assessment of metal exposure in fingernails of patients with nasopharyngeal cancer: a case study in Vietnamese men.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Metal ion homeostasis regulates condensin-dependent chromatin architecture and chromosome segregation in Schizosaccharomyces pombe.Journal of microbiology (Seoul, Korea) · 2025Article
- Trace Mineral Imbalances in Global Health: Challenges, Biomarkers, and the Role of Serum Analysis.Nutrients · 2025Review
- Review
- Heat stress in poultry: the role of nutritional supplements in alleviating heat stress and enhancing gut health in poultry.Frontiers in veterinary science · 2025Review
- Protective role of dietary zinc on DNA damage, oxidative stress, and metal toxicity.Frontiers in molecular biosciences · 2025Review
- Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients.Nutrients · 2024Article
- Catalytic activity of OGG1 is impaired by Zinc deficiency.DNA repair · 2024Article
- Zinc intake, SLC30A8 rs3802177 polymorphism, and colorectal cancer risk in a Korean population: a case-control study.Journal of cancer research and clinical oncology · 2023Article
- Induction of metallothionein expression by supplementation of zinc induces resistance against platinum-based treatment in malignant pleural mesothelioma.Translational cancer research · 2023Article
- Modulation of Zinc Transporter Expressions by Additional Zinc in C2C12 Cells Cultured in a High Glucose Environment and in the Presence of Insulin or Interleukin-6.Biological trace element research · 2023Article
- Zinc: From Biological Functions to Therapeutic Potential.International journal of molecular sciences · 2023Review
- Multifunctional role of zinc in human health: an update.EXCLI journal · 2023Review
- A compendium of Androgen Receptor Variant 7 target genes and their role in Castration Resistant Prostate Cancer.Frontiers in oncology · 2023Review
- Zinc in Prostate Health and Disease: A Mini Review.Biomedicines · 2022Review
- Zinc Prevents DNA Damage in Normal Cells but Shows Genotoxic and Cytotoxic Effects in Acute Myeloid Leukemia Cells.International journal of molecular sciences · 2022Article
- ZIP11 Regulates Nuclear Zinc Homeostasis in HeLa Cells and Is Required for Proliferation and Establishment of the Carcinogenic Phenotype.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Zinc is an essential trace element for human health and is a critical component of many proteins and transcription factors involved in DNA damage response and repair. The prostate is known to accumulate high levels of zinc, but levels are markedly decreased with cancer development. We hypothesized that zinc plays a critical role in maintaining DNA integrity in the prostate and zinc deficiency would lead to increased DNA damage and altered DNA damage response mechanisms. To test this hypothesis, the goal of this study was to determine the effects of zinc deficiency on DNA damage and DNA repair mechanisms by examining changes in global gene expression and transcription factor binding abilities in normal prostate epithelial cells (PrEC). Increased single-strand DNA breaks (Comet assay) were observed in PrEC grown in zinc-deficient media compared with cells grown in zinc-adequate media for 7 d. Using Affymetrix HG-U133A gene chips, differential expression of genes involved in cell cycle, apoptosis, transcription, and DNA damage response and repair were identified with low cellular zinc. Among genes involved in DNA damage response and repair, tumor protein p73, MRE11 meiotic recombination 11 homolog A, X-ray repair complementing defective repair in Chinese hamster cells 4, and breast cancer 2, early onset were down-regulated and TP53 was up-regulated. Additionally, western blotting showed increased nuclear p53 protein expression with zinc deficiency. Despite increased p53 gene and nuclear protein expression, there was no significant change in p53 binding activity. Zinc deficiency also induced an increase in binding activity of transcription factors involved in regulating cell proliferation and apoptosis. Thus, zinc deficiency may compromise DNA integrity in the prostate by impairing the function of zinc-containing proteins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.