ArticleMolecular endocrinology (Baltimore, Md.)2008
A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele.
Article in Molecular endocrinology (Baltimore, Md.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- The number of the CTCF binding sites of the H19/IGF2:IG-DMR correlates with DNA methylation and expression imprinting in a humanized mouse model.Human molecular genetics · 2021Article
- The Neglected Insulin: IGF-II, a Metabolic Regulator with Implications for Diabetes, Obesity, and Cancer.Cells · 2019Review
- CRISPR Cas9-guided chromatin immunoprecipitation identifies miR483 as an epigenetic modulator of IGF2 imprinting in tumors.Oncotarget · 2017Article
- Identifying multi-locus chromatin contacts in human cells using tethered multiple 3C.BMC genomics · 2015Article
- A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies.Nucleic acids research · 2014Article
- Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping.Nucleic acids research · 2014Article
- Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus.The Journal of cell biology · 2014Article
- Promoter histone H3K27 methylation in the control of IGF2 imprinting in human tumor cell lines.Human molecular genetics · 2014Article
- Beyond GWASs: illuminating the dark road from association to function.American journal of human genetics · 2013Review
- Article
- Long-range chromatin interactions at the mouse Igf2/H19 locus reveal a novel paternally expressed long non-coding RNA.Nucleic acids research · 2011Article
- Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome.Human molecular genetics · 2011Article
- A non-coding RNA within the Rasgrf1 locus in mouse is imprinted and regulated by its homologous chromosome in trans.PloS one · 2010Article
- Targeted tumor gene therapy based on loss of IGF2 imprinting.Cancer biology & therapy · 2010Article
- CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatin.Chromosoma · 2010Review
- 3D shortcuts to gene regulation.Current opinion in cell biology · 2010Review
- Loss of IGF2 imprinting is associated with abrogation of long-range intrachromosomal interactions in human cancer cells.Human molecular genetics · 2010Article
- Does CTCF mediate between nuclear organization and gene expression?BioEssays : news and reviews in molecular, cellular and developmental biology · 2010Review
- Article
- Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Alternate interactions between the H19 imprinting control region (ICR) and one of the two Igf2 differentially methylated regions has been proposed as a model regulating the reciprocal imprinting of Igf2 and H19. To study the conformation of this imprint switch, we performed a systematic structural analysis across the 140 kb of the mouse Igf2-H19 region, which includes enhancers located both between the two genes as well as downstream of H19, by using a scanning chromosome conformation capture (3C) technique. Our results suggest that on the active paternal Igf2 allele, the various enhancers have direct access to the Igf2 promoters, whereas the imprinted silent maternal Igf2 allele assumes a complex three-dimensional knotted loop that keeps the enhancers away from the Igf2 promoters and allows them to interact with the H19 promoter. This complex DNA looping of the maternal allele is formed by interactions involving differentially methylated region 1, the ICR, and enhancers. Binding of CTC-binding factor to the maternal, unmethylated ICR in conjunction with the presence of multicomplex components including interchromosomal interactions, create a barrier blocking the access of all enhancers to Igf2, thereby silencing the maternal Igf2. This silencing configuration exists in newborn liver, mouse embryonic fibroblast, and embryonic stem cells and persists during mitosis, conferring a mechanism for epigenetic memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.