ArticleCancer letters2008
Inhibition of heregulin mediated MCF-7 breast cancer cell growth by the ErbB3 binding protein EBP1.
Article in Cancer letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- PA2G4 in health and disease: An underestimated multifunctional regulator.Journal of advanced research · 2025Review
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- Transfer-RNA-mediated enhancement of ribosomal proteins S6 kinases signaling for cell proliferation.RNA biology · 2018Article
- Indolizine-Based Scaffolds as Efficient and Versatile Tools: Application to the Synthesis of Biotin-Tagged Antiangiogenic Drugs.ACS omega · 2017Article
- EBP1 protein modulates the expression of human MHC class II molecules in non-hematopoietic cancer cells.International journal of oncology · 2015Article
- The ErbB3-binding protein EBP1 modulates lapatinib sensitivity in prostate cancer cells.Molecular and cellular biochemistry · 2015Article
- Article
- A computational strategy to select optimized protein targets for drug development toward the control of cancer diseases.PloS one · 2015Article
- The downregulation of ErbB3 binding protein 1 (EBP1) is associated with poor prognosis and enhanced cell proliferation in hepatocellular carcinoma.Molecular and cellular biochemistry · 2014Article
- P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP.Cell death & disease · 2014Article
- ErbB3-binding protein EBP1 decreases ErbB2 levels via a transcriptional mechanism.Oncology reports · 2013Article
- Regulation of tamoxifen sensitivity by a PAK1-EBP1 signalling pathway in breast cancer.British journal of cancer · 2013Article
- P7 peptides suppress the proliferation of K562 cells induced by basic fibroblast growth factor.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast cancer cells.Breast cancer research and treatment · 2011Article
- Mechanism of antitumor effect of a novel bFGF binding peptide on human colon cancer cells.Cancer science · 2010Article
- Article
- Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice.BMC cell biology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The ErbB2/3 heterodimer plays a critical role in breast cancer genesis and progression. EBP1, an ErbB3 binding protein, inhibits breast cancer growth but its effects on ErbB3 ligand mediated signal transduction or ErbB receptors is not known. We report here that ectopic expression of EBP1 in MCF-7 and AU565 breast cancer cell lines inhibited HRG-induced proliferation. ErbB2 protein levels were substantially decreased in EBP1 transfectants, while ErbB3 levels were unchanged. HRG-induced AKT activation was attenuated in EBP1 stable transfectants and transfection of a constitutively activated AKT partially restored the growth response to HRG. Down-regulation of EBP1 expression in MCF-7 cells by shRNA resulted in increased cell growth in response to HRG and increased cyclin D1 and ErbB2 expression. These results suggest that EBP1, by down-regulating ErbB signal transduction, attentuates HRG-mediated growth of breast cancer cells.
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