ArticleAmerican journal of human genetics2008
Analysis of genomic admixture in Uyghur and its implication in mapping strategy.
Article in American journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Variant Rs556621 on Chromosome 6p21.1 and the Risk of Ischemic Stroke in Chinese Populations: A Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Biochemical metabolic levels and vitamin D receptor FokⅠ gene polymorphisms in Uyghur children with urolithiasis.PloS one · 2019Trial
- MtDNA genomes reveal a relaxation of selective constraints in low-BMI individuals in a Uyghur population.Human genetics · 2017Trial
- Association Between KCNQ1 Genetic Variants and Type 2 Diabetes in the Uyghur Population.Genetic testing and molecular biomarkers · 2015Trial
- Different Subjective and Objective Responses to Alcohol Among Heavy and Light Drinkers of Han and Uyghur Nationalities in China.Journal of addictions nursingTrial
- Admixture-driven structural variation diversity and its functional implications.National science review · 2026Article
- Divergent Eurasian ancestry and local adaptation shape the genetic landscapes of the Yugur and Uyghur.Briefings in bioinformatics · 2026Article
- Genomic landscape of the Great Steppe: Genetic variants in healthy Kazakh individuals.Scientific data · 2025Article
- Sex-Biased Admixture Followed by Isolation and Adaptive Evolution Shaped the Genomic and Blood Pressure Diversity of the LopNur People.Molecular biology and evolution · 2025Article
- Pilot work of the 10K Chinese People Genomic Diversity Project along the Silk Road suggests a complex east-west admixture landscape and biological adaptations.Science China. Life sciences · 2025Article
- Population genomics advances in frontier ethnic minorities in China.Science China. Life sciences · 2025Review
- Article
- Analysis of sex-biased gene expression in a Eurasian admixed population.Briefings in bioinformatics · 2024Article
- Ancestral Origins and Admixture History of Kazakhs.Molecular biology and evolution · 2024Article
- Ocular biometric characteristics of Han ethnicity in Tianjin and Uyghur ethnicity in Xinjiang undergoing cataract surgery.International journal of ophthalmology · 2024Article
- Expression profiles of east-west highly differentiated genes in Uyghur genomes.National science review · 2023Article
- Comparative Genomic and Transcriptomic Analyses Reveal the Impacts of Genetic Admixture in Kazaks, Uyghurs, and Huis.Molecular biology and evolution · 2023Article
- Myopia prevalence and ocular biometry: a cross-sectional study among minority versus Han schoolchildren in Xinjiang Uygur autonomous region, China.Eye (London, England) · 2022Article
- Article
- Genomic diversity and post-admixture adaptation in the Uyghurs.National science review · 2022Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Uyghur (UIG) population, settled in Xinjiang, China, is a population presenting a typical admixture of Eastern and Western anthropometric traits. We dissected its genomic structure at population level, individual level, and chromosome level by using 20,177 SNPs spanning nearly the entire chromosome 21. Our results showed that UIG was formed by two-way admixture, with 60% European ancestry and 40% East Asian ancestry. Overall linkage disequilibrium (LD) in UIG was similar to that in its parental populations represented in East Asia and Europe with regard to common alleles, and UIG manifested elevation of LD only within 500 kb and at a level of 0.1 <r(2) < 0.8 when ancestry-informative markers (AIMs) were used. The size of chromosomal segments that were derived from East Asian and European ancestries averaged 2.4 cM and 4.1 cM, respectively. Both the magnitude of LD and fragmentary ancestral chromosome segments indicated a long history of Uyghur. Under the assumption of a hybrid isolation (HI) model, we estimated that the admixture event of UIG occurred about 126 [107 approximately 146] generations ago, or 2520 [2140 approximately 2920] years ago assuming 20 years per generation. In spite of the long history and short LD of Uyghur compared with recent admixture populations such as the African-American population, we suggest that mapping by admixture LD (MALD) is still applicable in the Uyghur population but approximately 10-fold AIMs are necessary for a whole-genome scan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.