ArticleFEMS microbiology letters2008
OxyR is involved in coordinate regulation of expression of fimA and sod genes in Porphyromonas gingivalis.
Article in FEMS microbiology letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- OxyR regulates the oxidative stress response inApplied and environmental microbiology · 2026Article
- Identification of OxyR as an activator of type 1 fimbriae (Microbiology spectrum · 2025Article
- Hypochlorous acid solution serves as a potential anti-biofilm therapy for periodontitisJournal of oral microbiology · 2025Article
- Extracellular Vesicles ofLife (Basel, Switzerland) · 2023Article
- Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli.PLoS pathogens · 2022Article
- Direct current exerts electricidal and bioelectric effects on Porphyromonas gingivalis biofilms partially via promoting oxidative stress and antibiotic transport.Journal of microbiology (Seoul, Korea) · 2022Article
- Effects of the Quinone Oxidoreductase WrbA onAntioxidants (Basel, Switzerland) · 2021Article
- Expression patterns ofInfection and drug resistance · 2018Article
- Identification of Streptococcus cristatus peptides that repress expression of virulence genes in Porphyromonas gingivalis.Scientific reports · 2017Article
- Protein Analysis of Sapienic Acid-Treated Porphyromonas gingivalis Suggests Differential Regulation of Multiple Metabolic Pathways.Journal of bacteriology · 2016Article
- Identification of a diguanylate cyclase and its role in Porphyromonas gingivalis virulence.Infection and immunity · 2014Article
- Oxidative stress enhances the expression of sulfur assimilation genes: preliminary insights on the Enterococcus faecalis iron-sulfur cluster machinery regulation.Memorias do Instituto Oswaldo Cruz · 2014Article
- Antimicrobial strategies centered around reactive oxygen species--bactericidal antibiotics, photodynamic therapy, and beyond.FEMS microbiology reviews · 2013Review
- Structures of the Porphyromonas gingivalis OxyR regulatory domain explain differences in expression of the OxyR regulon in Escherichia coli and P. gingivalis.Acta crystallographica. Section D, Biological crystallography · 2013Article
- Peroxide-sensing transcriptional regulators in bacteria.Journal of bacteriology · 2012Review
- OxyR activation in Porphyromonas gingivalis in response to a hemin-limited environment.Infection and immunity · 2012Article
- Role of the Porphyromonas gingivalis extracytoplasmic function sigma factor, SigH.Molecular oral microbiology · 2012Article
- Oxidative stress resistance in Porphyromonas gingivalis.Future microbiology · 2012Review
- Differential expression and adherence of Porphyromonas gingivalis FimA genotypes.Molecular oral microbiology · 2011Article
- Porphyromonas gingivalis-dendritic cell interactions: consequences for coronary artery disease.Journal of oral microbiology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Survival of Porphyromonas gingivalis in the constantly changing oral environment depends on its ability to alter gene expression. We demonstrate here that P. gingivalis activates superoxide dismutase expression in response to oxidative stress and represses expression of FimA, a subunit of major fimbriae. Coordinated expression of fimA and sod is regulated by the redox-sensing transcription factor OxyR. Mutations in the oxyR gene result in a decreased expression of sod and in an elevated expression of fimA. In addition, we provide evidence that regulation of expression of fimA and sod by OxyR is mediated by direct interaction of OxyR and the promoters of these two genes. These results suggest that OxyR plays an important role in regulation of expression of virulence genes in P. gingivalis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.