ArticleFEMS yeast research2008
A TSC22-like motif defines a novel antiapoptotic protein family.
Article in FEMS yeast research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function.Molecular metabolism · 2022Article
- Yeast as a tool to decipher the molecular mechanisms underlying the functions of Bcl-2 family.Exploration of targeted anti-tumor therapy · 2022Review
- Identification of Binding Proteins for TSC22D1 Family Proteins Using Mass Spectrometry.International journal of molecular sciences · 2021Article
- Protein Homeostasis Networks and the Use of Yeast to Guide Interventions in Alzheimer's Disease.International journal of molecular sciences · 2020Review
- Article
- Loss of a Conserved tRNA Anticodon Modification Perturbs Plant Immunity.PLoS genetics · 2015Article
- Human Thyroid Cancer-1 (TC-1) is a vertebrate specific oncogenic protein that protects against copper and pro-apoptotic genes in yeast.Microbial cell (Graz, Austria) · 2015Article
- Establishment and Validation of an Orthotopic Metastatic Mouse Model of Colorectal Cancer.ISRN hepatology · 2013Article
- Boolean model of yeast apoptosis as a tool to study yeast and human apoptotic regulations.Frontiers in physiology · 2012Article
- Oxidative stress and programmed cell death in yeast.Frontiers in oncology · 2012Article
- Untangling the Roles of Anti-Apoptosis in Regulating Programmed Cell Death using Humanized Yeast Cells.Frontiers in oncology · 2012Article
- TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.Molecular and cellular biology · 2011Article
- Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence.The EMBO journal · 2011Article
- Harnessing gene expression to identify the genetic basis of drug resistance.Molecular systems biology · 2009Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The apoptotic programme is evolutionarily conserved between yeast and metazoan organisms. We have previously identified a number of mammalian cDNAs capable of suppressing the deleterious effects of Bax expression in yeast. We herein report that one such suppressor, named Tsc22((86)), represents the C-terminal 86 amino acids of the previously characterized leucine zipper (LZ) motif-containing transcriptional regulator Tsc22. Employing a genome-wide two-hybrid screen, functional genomics, and deletion mutagenesis approaches, we conclude that Tsc22((86))-mediated antiapoptosis is independent of the LZ motif and is likely independent of effects on gene transcription. Rather, a 16-residue sequence within the conserved 56-residue TSC22 domain is necessary for antiapoptosis. The presence of a similar sequence was used to predict an antiapoptotic role for two yeast proteins, Sno1p and Fyv10p. Overexpression and knock-out experiments were used to validate this prediction. These findings demonstrate the potential of studying heterologous proteins in yeast to uncover novel biological insights into the regulation of apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.