ArticleJournal of immunology (Baltimore, Md. : 1950)2008
The synthetic peroxisome proliferator-activated receptor-gamma agonist ciglitazone attenuates neuroinflammation and accelerates encapsulation in bacterial brain abscesses.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Role of JAK-STAT and PPAR-Gamma Signalling Modulators in the Prevention of Autism and Neurological Dysfunctions.Molecular neurobiology · 2022Review
- CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype.Journal of translational medicine · 2021Article
- Erythropoietin Promotes Infection Resolution and Lowers Antibiotic Requirements inFrontiers in immunology · 2021Article
- Immunopathogenesis of Craniotomy Infection and Niche-Specific Immune Responses to Biofilm.Frontiers in immunology · 2021Review
- Exploiting the Therapeutic Potential of Endogenous Immunomodulatory Systems in Multiple Sclerosis-Special Focus on the Peroxisome Proliferator-Activated Receptors (PPARs) and the Kynurenines.International journal of molecular sciences · 2019Review
- Enhanced Clearance of Pseudomonas aeruginosa by Peroxisome Proliferator-Activated Receptor Gamma.Infection and immunity · 2016Article
- PPARPPAR research · 2016Review
- Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease.The Journal of allergy and clinical immunology · 2015Article
- PPARγ and the Innate Immune System Mediate the Resolution of Inflammation.PPAR research · 2015Review
- Differential expression of transcription factors and inflammation-, ROS-, and cell death-related genes in organotypic cultures in the modiolus, the organ of Corti and the stria vascularis of newborn rats.Cellular and molecular neurobiology · 2014Article
- A dexamethasone prodrug reduces the renal macrophage response and provides enhanced resolution of established murine lupus nephritis.PloS one · 2013Article
- Dexamethasone prodrug treatment prevents nephritis in lupus-prone (NZB × NZW)F1 mice without causing systemic side effects.Arthritis and rheumatism · 2012Article
- Article
- Central nervous system fibrosis is associated with fibrocyte-like infiltrates.The American journal of pathology · 2011Article
- Roles of Toll-like receptor 2 (TLR2) and superantigens on adaptive immune responses during CNS staphylococcal infection.Brain, behavior, and immunity · 2011Article
- IL-13 downregulates PPAR-gamma/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death.Cellular and molecular life sciences : CMLS · 2010Article
- Evaluation of capsular and acapsular strains of S. aureus in an experimental brain abscess model.Journal of neuroimmunology · 2010Article
- MyD88 expression by CNS-resident cells is pivotal for eliciting protective immunity in brain abscesses.ASN neuro · 2009Article
- TLR2 expression in astrocytes is induced by TNF-alpha- and NF-kappa B-dependent pathways.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation.Journal of neurochemistry · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Brain abscesses result from a pyogenic parenchymal infection commonly initiated by Gram-positive bacteria such as Staphylococcus aureus. Although the host immune response elicited following infection is essential for effective bacterial containment, this response also contributes to the significant loss of brain parenchyma by necrosis that may be reduced by modulating the inflammatory response. Ciglitazone, a PPAR-gamma agonist with anti-inflammatory properties, was evaluated for its ability to influence the course of brain abscess development when treatment was initiated 3 days following infection. Interestingly, abscess-associated bacterial burdens were significantly lower following ciglitazone administration, which could be explained, in part, by the finding that ciglitazone enhanced S. aureus phagocytosis by microglia. In addition, ciglitazone attenuated the expression of select inflammatory mediators during brain abscess development including inducible NO synthase, TNF-alpha, IL-1beta, CXCL2, and CCL3. Unexpectedly, ciglitazone also accelerated brain abscess encapsulation, which was typified by the heightened expression of fibronectin and alpha-smooth muscle actin-positive myofibroblasts. Collectively, through its ability to attenuate excessive inflammation and accelerate abscess encapsulation, ciglitazone may effectively sequester brain abscesses and limit bacterial dissemination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.