ReviewJournal of immunology (Baltimore, Md. : 1950)2008
Modulation of dendritic cell function by Leishmania parasites.
Review in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 92 citations in OpenAlex.
- Platelet DKK1 promotes tolerogenic dendritic cells and non-healing responses in cutaneous leishmaniasis.iScience · 2026Article
- Indirect CD4Journal of virology · 2024Article
- ExploitingCells · 2024Article
- Enhancing Control ofAnimals : an open access journal from MDPI · 2024Article
- Transcriptome Analysis Identifies the Crosstalk between Dendritic and Natural Killer Cells in Human Cutaneous Leishmaniasis.Microorganisms · 2023Article
- Transcriptional Profiling ofMicroorganisms · 2022Article
- Mast-Cell Response toPathogens (Basel, Switzerland) · 2022Article
- Role of Cytokines in Experimental and Human Visceral Leishmaniasis.Frontiers in cellular and infection microbiology · 2021Review
- Determinants of Innate Immunity in Visceral Leishmaniasis and Their Implication in Vaccine Development.Frontiers in immunology · 2021Review
- Review
- Role of Host and Parasite MIF Cytokines duringTropical medicine and infectious disease · 2020Review
- Article
- CD4Frontiers in cellular and infection microbiology · 2019Article
- Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View.Frontiers in immunology · 2019Review
- Type I Interferon Signaling Is Required for CpG-Oligodesoxynucleotide-Induced Control ofFrontiers in immunology · 2018Article
- Review
- The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis.Frontiers in immunology · 2017Review
- Cutaneous leishmaniasis: immune responses in protection and pathogenesis.Nature reviews. Immunology · 2016Review
- Leishmania-encoded orthologs of macrophage migration inhibitory factor regulate host immunity to promote parasite persistence.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Leishmania major Promastigotes Evade LC3-Associated Phagocytosis through the Action of GP63.PLoS pathogens · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The interactions between Leishmania parasites and dendritic cells (DCs) are complex and involve paradoxical functions that can stimulate or halt T cell responses, leading to the control of infection or progression of disease. The magnitude and profile of DC activation vary greatly, depending upon the Leishmania species/strains, developmental stages, DC subsets, serum opsonization, and exogenous DC stimuli involved in the study. In general, the uptake of Leishmania parasites alone can trigger relatively weak and transient DC activation; however, the intracellular parasites (amastigotes) are capable of down-modulating LPS/IFN-gamma-stimulated DC activation via multiple mechanisms. This review will highlight current data regarding the initial interaction of DC subsets with invading parasites, the alterations of DC signaling pathways and function by amastigotes, and the impact of DC functions on protective immunity and disease pathogenesis. Available information provides insight into the mechanisms by which DCs discriminate between the types of pathogens and regulate appropriate immune responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.