Evidence map›Paper›PMID 18354101›Full record

ArticleThe New England journal of medicine2008

Duration of red-cell storage and complications after cardiac surgery.

Colleen Gorman Koch, Liang Li, Daniel I Sessler, Priscilla Figueroa, Gerald A Hoeltge, Tomislav Mihaljevic, Eugene H Blackstone

5 registry-linked trialsOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in The New England journal of medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 403 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
403citing papers in PubMed, 5 pooled it
55.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01185600 nacompletednot on this mapstarted 2010, after this paper: background citation

Microparticles in Stored Red Blood Cells (RBC) as Potential Mediators of Transfusion Complications (II): Clinical Study

TypeinterventionalSponsorUniversity of MiamiRan2010 to 2015Enrolled177ConditionsCoronary Artery BypassArmsWashed RBC, Unwashed RBC
NCT01226498 nacompletednot on this mapstarted 2010, after this paper: background citation

Effects of Duration of Stored Red Blood Cell Transfusion on Physiological Parameters and Inflammatory Mediators in Healthy Adult Volunteers

TypeinterventionalSponsorMassachusetts General HospitalRan2010 to 2011Enrolled10ConditionsBlood Transfusion, AutologousArmsRed blood Cells auto-transfusion
NCT01529502 phase2completednot on this mapstarted 2012, after this paper: background citation

Effects of Stored Red Blood Cell Transfusion in Overweight Subjects With Endothelial Dysfunction: Influence of Inhaled Nitric Oxide (iNO)

TypeinterventionalSponsorMassachusetts General HospitalRan2012 to 2013Enrolled14ConditionsBlood Transfusion, Endothelial Physiopathology, Nitric Oxide, Pulmonary HypertensionArmsRed blood Cells auto-transfusion, Inhaled Nitric Oxide (iNO) administration
NCT02020525 nacompletednot on this map

The Impact of Lowering Transfusion Trigger on Patient Immune Response During Major Abdominal Surgery

TypeinterventionalSponsorAretaieion University HospitalRan2004 to 2007Enrolled58ConditionsInfection After Transfusion, Transfusion-related Immunomodulation Reaction, Cytokine Storm, SurgeryArmsrestrictive transfusion strategy, liberal transfusion strategy
NCT02393508 phase3unknown statusnot on this mapstarted 2015, after this paper: background citation

The Impact of Red Cell Age on Product Utilization in the Chronically Transfused Outpatient Population

TypeinterventionalSponsorUniversity of CalgaryRan2015 to 2017Enrolled60ConditionsBone Marrow Failure SyndromeArmsFresh Human Red Blood Cells, Aged Human Red Blood Cells
3 · Its place in the literature

Who cites it

403 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,370 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Impact of the age of stored blood on trauma patient mortality: a systematic review.Canadian journal of surgery. Journal canadien de chirurgie · 2015
    Pooled it
  5. Prolonged storage of packed red blood cells for blood transfusion.The Cochrane database of systematic reviews · 2015
    Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
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  13. The impact of red blood cell storage duration on tissue oxygenation in cardiac surgery.The Journal of thoracic and cardiovascular surgery · 2017
    Trial
  14. Effects of Aged Stored Autologous Red Blood Cells on Human Endothelial Function.American journal of respiratory and critical care medicine · 2015
    Trial
  15. Trial
  16. Trial
  17. Trial
  18. Article
  19. Article
  20. Review

343 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Colleen Gorman KochDepartment of Cardiothoracic Anesthesia, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. kochc@ccf.org
Liang Li
Daniel I Sessler
Priscilla Figueroa
Gerald A Hoeltge
Tomislav Mihaljevic
Eugene H Blackstone
Cleveland Clinic · US

Funding

Nitrous Oxide and Wound InfectionsR01GM061655 · NIGMS · UNIVERSITY OF LOUISVILLE · PI AKCA, OZAN · 2003 to 2006
$437k
NIGMS NIH HHS GM 061655
6 · The paper itself

Abstract

backgroundStored red cells undergo progressive structural and functional changes over time. We tested the hypothesis that serious complications and mortality after cardiac surgery are increased when transfused red cells are stored for more than 2 weeks.

methodsWe examined data from patients given red-cell transfusions during coronary-artery bypass grafting, heart-valve surgery, or both between June 30, 1998, and January 30, 2006. A total of 2872 patients received 8802 units of blood that had been stored for 14 days or less ("newer blood"), and 3130 patients received 10,782 units of blood that had been stored for more than 14 days ("older blood"). Multivariable logistic regression with propensity-score methods was used to examine the effect of the duration of storage on outcomes. Survival was estimated by the Kaplan-Meier method and Blackstone's decomposition method.

resultsThe median duration of storage was 11 days for newer blood and 20 days for older blood. Patients who were given older units had higher rates of in-hospital mortality (2.8% vs. 1.7%, P=0.004), intubation beyond 72 hours (9.7% vs. 5.6%, P<0.001), renal failure (2.7% vs. 1.6%, P=0.003), and sepsis or septicemia (4.0% vs. 2.8%, P=0.01). A composite of complications was more common in patients given older blood (25.9% vs. 22.4%, P=0.001). Similarly, older blood was associated with an increase in the risk-adjusted rate of the composite outcome (P=0.03). At 1 year, mortality was significantly less in patients given newer blood (7.4% vs. 11.0%, P<0.001).

conclusionsIn patients undergoing cardiac surgery, transfusion of red cells that had been stored for more than 2 weeks was associated with a significantly increased risk of postoperative complications as well as reduced short-term and long-term survival.

Indexed as

Blood PreservationCardiac Surgical ProceduresErythrocytesAgedCoronary Artery BypassErythrocyte TransfusionFemaleHeart ValvesHospital MortalityHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedPostoperative ComplicationsRenal Insufficiency

Identifiers

PMID18354101
OpenAlexW2107921622

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.