ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Hypocretin-1 potentiates NMDA receptor-mediated somatodendritic secretion from locus ceruleus neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Orexin System in Addiction: Neuromodulatory Interactions and Therapeutic Potential.Brain sciences · 2025Review
- Decrease of inhibitory synaptic currents of locus coeruleus neurons via orexin type 1 receptors in the context of naloxone-induced morphine withdrawal.The journal of physiological sciences : JPS · 2019Article
- Bidirectional and context-dependent changes in theta and gamma oscillatory brain activity in noradrenergic cell-specific Hypocretin/Orexin receptor 1-KO mice.Scientific reports · 2018Article
- To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance.Frontiers in systems neuroscience · 2015Review
- Orexin A attenuates the sleep-promoting effect of adenosine in the lateral hypothalamus of rats.Neuroscience bulletin · 2014Article
- Orexin/hypocretin receptor signalling: a functional perspective.British journal of pharmacology · 2014Article
- Central functions of the orexinergic system.Neuroscience bulletin · 2013Review
- Differential roles of orexin receptors in the regulation of sleep/wakefulness.Frontiers in endocrinology · 2013Article
- Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system.Frontiers in physiology · 2012Article
- Physiology of quantal norepinephrine release from somatodendritic sites of neurons in locus coeruleus.Frontiers in molecular neuroscience · 2012Article
- Coordination of rhythm-generating units via NO and extrasynaptic neurotransmitter release.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2010Article
- Direct and decarboxylation-dependent effects of neurotransmitter precursors on firing of isolated monoaminergic neurons.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2009Article
- Orexin A-induced extracellular calcium influx in prefrontal cortex neurons involves L-type calcium channels.Journal of physiology and biochemistry · 2009Article
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Authors and funding
17 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our previous observations showed that several stimuli, including high-K(+) solution, glutamate, and voltage pulses, induce somatic noradrenaline (NA) secretion from locus ceruleus (LC) neurons. Hypocretin (orexin), a hypothalamic peptide critical for normal wakefulness, has been shown to evoke NA release from the axon terminals of LC neurons. Here, we used amperometry to test the effect of hypocretin-1 (HCRT) on NMDA receptor-mediated somatodendritic release in LC neurons. Either HCRT or NMDA applied alone dose-dependently induced somatodendritic secretion. Bath application of HCRT notably potentiated NMDA receptor-mediated somatodendritic NA release. This potentiation was blocked by SB 334867, a selective HCRT receptor (Hcrtr 1) antagonist, or bisindolylmaleimide, a specific protein kinase C (PKC) inhibitor, indicating the involvement of Hcrtr 1 and PKC. Consistent with this, phorbol 12-myristate 13-acetate, a PKC activator, mimicked the HCRT-induced potentiation. Furthermore, HCRT enhanced NMDA-induced intracellular Ca(2+) elevation via activation of Hcrtr 1 and PKC, which may contribute to HCRT-potentiated somatodendritic secretion. These results suggest that HCRT modulates LC activity not only by regulating noradrenergic input to its targets, but also by affecting noradrenergic communication in the soma and dendrites.
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