ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Evidence for muscle-dependent neuromuscular synaptic site determination in mammals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Maturation of a postsynaptic domain: Role of small Rho GTPases in organising nicotinic acetylcholine receptor aggregates at the vertebrate neuromuscular junction.Journal of anatomy · 2022Review
- Structure and Function of the Mammalian Neuromuscular Junction.Comprehensive Physiology · 2022Article
- Motor function recovery: deciphering a regenerative niche at the neuromuscular synapse.Biological reviews of the Cambridge Philosophical Society · 2021Review
- Motor endplate-expressing cartilage-muscle implants for reconstruction of a denervated hemilarynx.The Laryngoscope · 2019Article
- Animal Models of the Neuromuscular Junction, Vitally Informative for Understanding Function and the Molecular Mechanisms of Congenital Myasthenic Syndromes.International journal of molecular sciences · 2018Review
- Neuromuscular Junctions as Key Contributors and Therapeutic Targets in Spinal Muscular Atrophy.Frontiers in neuroanatomy · 2016Review
- Wnt signaling in skeletal muscle dynamics: myogenesis, neuromuscular synapse and fibrosis.Molecular neurobiology · 2014Review
- Stem cell-derived tissue-engineered constructs for hemilaryngeal reconstruction.The Annals of otology, rhinology, and laryngology · 2014Article
- Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.Frontiers in cellular neuroscience · 2014Article
- Novel mouse model reveals distinct activity-dependent and -independent contributions to synapse development.PloS one · 2011Article
- The Wnt and BMP families of signaling morphogens at the vertebrate neuromuscular junction.International journal of molecular sciences · 2011Review
- Skeletal muscle in motor neuron diseases: therapeutic target and delivery route for potential treatments.Current drug targets · 2010Review
- To build a synapse: signaling pathways in neuromuscular junction assembly.Development (Cambridge, England) · 2010Review
- Tyrosine phosphorylation of nuclear-membrane protein emerin by Src, Abl and other kinases.Journal of cell science · 2009Article
- Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor.Neuron · 2009Article
- Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent evidence challenges the prevalent view that neural factors induce the formation of a de novo postsynaptic apparatus during development of the vertebrate neuromuscular junction. The latest experiments suggest an alternative model in which the muscle fiber induces a nascent postsynaptic apparatus and sets the location of the future synapse. On axonal contact, these sites, laid out in a prepattern in the central area of developing muscle fibers, mature into synapses by the combined action of neural factors such as agrin and ACh. We sought to test in mammals these two models of neuromuscular synaptogenesis. Previously, we showed that continuous prenatal muscle expression of constitutively active ErbB2 (CAErbB2) led to synaptic loss, exuberant axonal sprouting, and lethality at birth. Here, we transiently induced CAErbB2 during midgestation and examined synapse restoration after inducer withdrawal. Centrally enriched ACh receptor (AChR) transcription and clustering were abolished after transient CAErbB2 induction. After inducer withdrawal, synapses were restored but were distributed widely over the entire diaphragm muscle. Under the nerve-dependent model, this distribution is explained by the wide pattern of axonal sprouting triggered by CAErbB2. Yet, in the absence of the nerve, introduced in our animals by mating to Hb9(+/-) mice, a very similar, wide distribution of aneural AChR clusters resulted. Thus, transient expression of CAErbB2 in skeletal muscles leads to reprogramming of the endogenous muscle AChR prepattern. This, and not the nerve, seems primarily responsible for the widely distributed pattern of synapses in our experimental animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.