ArticleClinical and vaccine immunology : CVI2008
Sex-dependent differences in plasma cytokine responses to hantavirus infection.
Article in Clinical and vaccine immunology : CVI, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica.BioMed research international · 2022Trial
- Hantavirus seroprevalence and associated factors for exposure in south-central Uganda.Emerging microbes & infections · 2026Article
- Replication kinetics of pathogenic Eurasian orthohantaviruses in human mesangial cells.Virology journal · 2024Article
- Glomerular Injury Is Associated with Severe Courses of Orthohantavirus Infection.Pathogens (Basel, Switzerland) · 2024Article
- Assessment of gender differences in some inflammatory cytokines of tuberculosis patients before and during treatment.African health sciences · 2023Article
- Hantavirus: an overview and advancements in therapeutic approaches for infection.Frontiers in microbiology · 2023Review
- Cytokines profile in neonatal and adult wild-type mice post-injection of U. S. pediatric vaccination schedule.Brain, behavior, & immunity - health · 2021Article
- Disruption of type I interferon signaling causes sexually dimorphic dysregulation of anti-viral cytokines.Cytokine: X · 2021Article
- Preterm birth and sustained inflammation: consequences for the neonate.Seminars in immunopathology · 2020Review
- Relationship between sex hormones and RIG-I signaling in peripheral blood mononuclear cells of patients infected with hepatitis C virus.Experimental and therapeutic medicine · 2017Article
- Exposure Characteristics of Hantavirus Pulmonary Syndrome Patients, United States, 1993-2015.Emerging infectious diseases · 2017Article
- Depletion of Alveolar Macrophages Does Not Prevent Hantavirus Disease Pathogenesis in Golden Syrian Hamsters.Journal of virology · 2016Article
- Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors.Arteriosclerosis, thrombosis, and vascular biology · 2015Observational
- Hantavirus-induced disruption of the endothelial barrier: neutrophils are on the payroll.Frontiers in microbiology · 2015Article
- Surveillance of hantaviruses in Poland: a study of animal reservoirs and human hantavirus disease in Subcarpathia.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2014Article
- No gender-related differences in the severity of nephropathia epidemica, Germany.BMC infectious diseases · 2013Article
- Establishment of SYBR green-based qPCR assay for rapid evaluation and quantification for anti-Hantaan virus compounds in vitro and in suckling mice.Virus genes · 2013Article
- Elevated cerebrospinal fluid neopterin concentration is associated with disease severity in acute Puumala hantavirus infection.Clinical & developmental immunology · 2013Article
- Sex differences in murine susceptibility to systemic viral infections.Journal of autoimmunity · 2012Article
- Pathogenic old world hantaviruses infect renal glomerular and tubular cells and induce disassembling of cell-to-cell contacts.Journal of virology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are often sex differences in susceptibility to infectious diseases and in level of mortality after infection. These differences probably stem from sex-related abilities to mount proper or unwanted immune responses against an infectious agent. We report that hantavirus-infected female patients show significantly higher plasma levels of interleukin-9 (IL-9), fibroblast growth factor 2, and granulocyte-macrophage colony-stimulating factor and lower levels of IL-8 and gamma interferon-induced protein 10 than male patients. The results demonstrate that a virus infection can induce sex-dependent differences in acute immune responses in humans. This finding may, at least partly, explain the observed sex differences in susceptibility to infectious diseases and in mortality following infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.