ArticleVirus research2008
Genetic variation of hepatitis C virus in a cohort of injection heroin users in Wuhan, China.
Article in Virus research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01095445 (EXtended Therapy in Genotype 3 Infected Patients Who do Not AChieve a Treatment Response at Week 4), which is not on this map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
EXtended Therapy in Genotype 3 Infected Patients Who do Not AChieve a Treatment Response at Week 4 (RVR) But do Achieve a Complete Early Virologic Response (cEVR)
Who cites it
15 citing papers in PubMed.
- Article
- The distinct epidemic characteristics of HCV co-infection among HIV-1-infected population caused by drug injection and sexual transmission in Yunnan, China.Epidemiology and infection · 2019Article
- Assessment of HCV genotypes in Yunnan Province of Southwest China.Virus genes · 2017Article
- Exploratory social network analysis and gene sequencing in people who inject drugs infected with hepatitis C virus.Epidemiology and infection · 2016Article
- Current status and emerging challenges in the treatment of hepatitis C virus genotypes 4 to 6.World journal of clinical cases · 2015Review
- Genotype Distribution and Molecular Epidemiology of Hepatitis C Virus in Hubei, Central China.PloS one · 2015Article
- Migration patterns of hepatitis C virus in China characterized for five major subtypes based on samples from 411 volunteer blood donors from 17 provinces and municipalities.Journal of virology · 2014Article
- The current hepatitis C virus prevalence in China may have resulted mainly from an officially encouraged plasma campaign in the 1990s: a coalescence inference with genetic sequences.Journal of virology · 2013Article
- Advances in genetic studies of substance abuse in China.Shanghai archives of psychiatry · 2013Review
- Epidemiology of hepatitis C virus infection and risk factor analysis in the Hebei Province, China.PloS one · 2013Article
- Changing pattern of clinical epidemiology on hepatitis C virus infection in southwest china.Hepatitis monthly · 2012Article
- Article
- HCV subtype characterization among injection drug users: implication for a crucial role of Zhenjiang in HCV transmission in China.PloS one · 2011Article
- New trends of HCV infection in China revealed by genetic analysis of viral sequences determined from first-time volunteer blood donors.Journal of viral hepatitis · 2011Article
- Molecular and contextual markers of hepatitis C virus and drug abuse.Molecular diagnosis & therapy · 2009Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Since the majority of heroin abusers use injection as the primary route of admission, heroin abuse contributes significantly to the transmission of hepatitis C virus (HCV). We determined HCV infection and its genotype distribution among injection heroin users in Wuhan, the largest city in the central China. Eight hundred seventy-eight (84%) out of 1046 serum specimens from the injection drug users were positive for HCV antibody. Out of randomly selected 122 specimens positive for HCV antibody, seventy-eight (64%) had detectable HCV RNA with genotype 6a as the predominant strain (50%), followed by 3b (32.2%), 1a (8.1%), 1b (6.5%), and 3a (3.2%). HCV RNA levels in male heroin users were significantly higher (P=0.013) than those in the female subjects. Although there was no significant difference in HCV RNA levels among the specimens positive for HCV 6a and 1a/1b, the samples with 6a or 1a/1b contained higher levels of HCV RNA than the specimens positive for HCV 3b (P=0.019, P=0.012, respectively). These findings indicate that there is a high prevalence of HCV infection with genotypes 6a and 3b as predominated strains among injection heroin users in Wuhan, China.
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