ArticlePharmacology, biochemistry, and behavior2008
Baclofen, raclopride, and naltrexone differentially reduce solid fat emulsion intake under limited access conditions.
Article in Pharmacology, biochemistry, and behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- GABAMedComm · 2025Review
- Food Addiction.Brain sciences · 2024Review
- GABAiScience · 2019Article
- Review
- A behavioral and pharmacological characterization of palatable diet alternation in mice.Pharmacology, biochemistry, and behavior · 2017Article
- Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats.Journal of visualized experiments : JoVE · 2016Article
- Can We Selectively Reduce Appetite for Energy-Dense Foods? An Overview of Pharmacological Strategies for Modification of Food Preference Behavior.Current neuropharmacology · 2016Review
- Development of bingeing in rats altered by a small operant requirement.Physiology & behavior · 2015Article
- Intermittent-access binge consumption of sweet high-fat liquid does not require opioid or dopamine receptors in the nucleus accumbens.Behavioural brain research · 2015Article
- Hormonal and neural mechanisms of food reward, eating behaviour and obesity.Nature reviews. Endocrinology · 2014Review
- Addicted to palatable foods: comparing the neurobiology of Bulimia Nervosa to that of drug addiction.Psychopharmacology · 2014Review
- Mu opioid receptor antagonism in the nucleus accumbens shell blocks consumption of a preferred sucrose solution in an anticipatory contrast paradigm.Neuroscience · 2014Article
- Article
- Intermittent access to sweet high-fat liquid induces increased palatability and motivation to consume in a rat model of binge consumption.Physiology & behavior · 2013Article
- Involvement of the endogenous opioid system in the psychopharmacological actions of ethanol: the role of acetaldehyde.Frontiers in behavioral neuroscience · 2013Article
- Roles of dopamine D1 and D2 receptors in the acquisition and expression of fat-conditioned flavor preferences in rats.Neurobiology of learning and memory · 2012Article
- Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use.ILAR journal · 2012Review
- Article
- Feeding and reward: perspectives from three rat models of binge eating.Physiology & behavior · 2011Review
- Reinforcing efficacy of fat, as assessed by progressive ratio responding, depends upon availability not amount consumed.Physiology & behavior · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Previous work in rats has demonstrated that an Intermittent (Monday, Wednesday, Friday) schedule of access promotes binge-type consumption of 100% vegetable shortening during a 1-h period of availability. The present study used novel shortening-derived stable solid emulsions of various fat concentrations. These emulsions were the consistency of pudding and did not demonstrate oil and water phase separation previously reported with oil-based liquid emulsions. Male Sprague-Dawley rats were grouped according to schedule of access (Daily or Intermittent) to one of three concentrations (18%, 32%, 56%) of solid fat emulsion. There were no significant Intermittent vs. Daily differences in amount consumed, due to high intakes in all groups. This indicated the acceptability of the emulsions. Baclofen (GABA(B) agonist) and raclopride (D2-like antagonist) both significantly reduced emulsion intake in all Daily groups, but only in the 56% fat Intermittent group. Naltrexone (opioid antagonist), in contrast, significantly reduced 32% and 56% fat emulsion intake in the Intermittent, as well as the Daily groups. These results indicate that the fat intake-reducing effects of GABA(B) activation and D(2) blockade depend upon fat concentration and schedule of fat access, while the fat intake-reducing effects of opioid blockade depend upon fat concentration but not schedule of access.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.