ArticleDevelopmental biology2008
Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Article
- Article
- Repression of transcription factor AP-2 alpha by PPARγ reveals a novel transcriptional circuit in basal-squamous bladder cancer.Oncogenesis · 2019Article
- TFAP2C regulates transcription in human naive pluripotency by opening enhancers.Nature cell biology · 2018Article
- Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs.Scientific reports · 2016Article
- The AP-2 Transcription Factor APTF-2 Is Required for Neuroblast and Epidermal Morphogenesis in Caenorhabditis elegans Embryogenesis.PLoS genetics · 2016Article
- Palatogenesis and cutaneous repair: A two-headed coin.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Transcriptional regulation of the human TNFSF11 gene in T cells via a cell type-selective set of distal enhancers.Journal of cellular biochemistry · 2015Article
- TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis.Oncogene · 2015Article
- A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms.Nucleic acids research · 2015Article
- Transcriptional profiling of ectoderm specification to keratinocyte fate in human embryonic stem cells.PloS one · 2015Article
- Expression pattern of clinically relevant markers in paediatric germ cell- and sex-cord stromal tumours is similar to adult testicular tumours.Virchows Archiv : an international journal of pathology · 2014Article
- An Intimate Relationship between Thyroid Hormone and Skin: Regulation of Gene Expression.Frontiers in endocrinology · 2013Article
- AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning.Cell research · 2012Article
- Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation.Nucleic acids research · 2012Article
- An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate.PloS one · 2009Article
- Maternal Interferon Regulatory Factor 6 is required for the differentiation of primary superficial epithelia in Danio and Xenopus embryos.Developmental biology · 2009Article
- AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.The Journal of cell biology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Summary Sentence: Conditional ablation of AP-2 gamma results in a delay in skin development and abnormal expression of p63, K14, K1, filaggrin, repetin and secreted Ly6/Plaur domain containing 1, key genes required for epidermal development and differentiation. The development of the epidermis, a stratified squamous epithelium, is dependent on the regulated differentiation of keratinocytes. Differentiation begins with the initiation of stratification, a process tightly controlled through proper gene expression. AP-2 gamma is expressed in skin and previous research suggested a pathway where p63 gene induction results in increased expression of AP-2 gamma, which in turn is responsible for induction of K14. This study uses a conditional gene ablation model to further explore the role of AP-2 gamma in skin development. Mice deficient for AP-2 gamma exhibited delayed expression of p63, K14, and K1, key genes required for development and differentiation of the epidermis. In addition, microarray analysis of E16.5 skin revealed delayed expression of additional late epidermal differentiation genes: filaggrin, repetin and secreted Ly6/Plaur domain containing 1, in mutant mice. The genetic delay in skin development was further confirmed by a functional delay in the formation of an epidermal barrier. These results document an important role for AP-2 gamma in skin development, and reveal the existence of regulatory factors that can compensate for AP-2 gamma in its absence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.