ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2008
Zebrafish sip1a and sip1b are essential for normal axial and neural patterning.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Genetic regulation of enteric nervous system development in zebrafish.Biochemical Society transactions · 2024Review
- Review
- An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution.eLife · 2021Article
- Genetics Underlying the Interactions between Neural Crest Cells and Eye Development.Journal of developmental biology · 2020Review
- Article
- Migration and diversification of the vagal neural crest.Developmental biology · 2018Review
- The role of TGF-β superfamily signaling in neurological disorders.Acta biochimica et biophysica Sinica · 2018Review
- RGC32 induces epithelial-mesenchymal transition by activating the Smad/Sip1 signaling pathway in CRC.Scientific reports · 2017Article
- Spemann organizer gene Goosecoid promotes delamination of neuroblasts from the otic vesicle.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT.The Journal of cell biology · 2013Article
- Zebrafish churchill regulates developmental gene expression and cell migration.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Article
- Development of the zebrafish enteric nervous system.Methods in cell biology · 2011Review
- Spatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation.BMC genomics · 2010Article
- FGF dependent regulation of Zfhx1b gene expression promotes the formation of definitive neural stem cells in the mouse anterior neurectoderm.Neural development · 2010Article
- Churchill and Sip1a repress fibroblast growth factor signaling during zebrafish somitogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease.Neurogastroenterology and motility · 2009Review
- Diversity in the molecular and cellular strategies of epithelium-to-mesenchyme transitions: Insights from the neural crest.Cell adhesion & migrationArticle
- Signaling Molecules Governing Pluripotency and Early Lineage Commitments in Human Pluripotent Stem Cells.Cell journalReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Smad-interacting protein-1 (SIP1) has been implicated in the development of Mowat-Wilson syndrome whose patients exhibit Hirschsprung disease, an aganglionosis of the large intestine, as well as other phenotypes. We have identified and cloned two sip1 orthologues in zebrafish. Both sip1 orthologues are expressed maternally and have dynamic zygotic expression patterns that are temporally and spatially distinct. We have investigated the function of both orthologues using translation and splice-blocking morpholino antisense oligonucleotides. Knockdown of the orthologues causes axial and neural patterning defects consistent with the previously described function of SIP1 as an inhibitor of BMP signaling. In addition, knockdown of both genes leads to a significant reduction/loss of the post-otic cranial neural crest. This results in a subsequent absence of neural crest precursors in the posterior pharyngeal arches and a loss of enteric precursors in the intestine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.