ReviewDigestive diseases and sciences2008
Gastrointestinal manifestations of Henoch-Schonlein Purpura.
Review in Digestive diseases and sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 188 citations in OpenAlex.
- Abdominal pain in pediatric immunoglobulin A vasculitis: Risk factors and severity predictors in a multicenter cohort.Journal of pediatric gastroenterology and nutrition · 2026Article
- Immunoglobulin A Vasculitis-Associated Ileoileal Intussusception in an Adult Male: Case Report.Clinical practice and cases in emergency medicine · 2026Article
- Review
- Systemic and dermatological findings of immunoglobulin A vasculitis in a black child: A case report.World journal of clinical cases · 2025Article
- Therapeutic success of factor XIII substitution for IgA vasculitis with gastrointestinal manifestation.Clinical journal of gastroenterology · 2025Article
- A case-based review of IgA vasculitis complicated with gastrointestinal infections: insights from a norovirus-associated case in an adolescent.Rheumatology international · 2025Review
- Early discontinuation of steroid treatment in children with abdominal pain due to IgA vasculitis.European journal of pediatrics · 2025Article
- Immunoglobulin A Vasculitis Following COVID-19 Infection in an Adolescent Girl.Oman medical journal · 2025Article
- Case Report: Severe gastrointestinal complications in adult IgA vasculitis: a fatal case of acute esophageal necrosis.Frontiers in immunology · 2025Article
- A specific diagnostic metabolome signature in adult IgA vasculitis.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Terminal ileitis: a rare gastrointestinal manifestation of IgA vasculitis in a child.BMJ case reports · 2024Article
- [Immunoglobulin A vasculitis].Innere Medizin (Heidelberg, Germany) · 2024Review
- Gastrointestinal manifestations and pathogenesis in childhood immunoglobulin A vasculitis.Frontiers in pediatrics · 2024Review
- ASSOCIATION BETWEEN HIGH MOBILITY GROUP BOX 1 PROTEIN GENE (rs41369348) POLYMORPHISM AND IMMUNOGLOBULIN A VASCULITIS IN CHILDREN.Acta clinica Croatica · 2023Article
- Acute pancreatitis associated with immunoglobulin A vasculitis: report of fifteen cases.Clinical rheumatology · 2023Article
- Serum total bile acid levels assist in the prediction of acute intussusception with abdominal type Henoch-Schonlein purpura in children.Frontiers in pediatrics · 2023Article
- An Immunoglobulin A Vasculitis Case Without Skin Symptoms Complicated With Severe Abdominal Symptoms.Journal of medical cases · 2022Article
- Relevance of Intestinal Microbiota in Immunoglobulin A Vasculitis With Abdominal Involvement.Frontiers in pediatrics · 2022Article
- Gastrointestinal involvement in IgA vasculitis: a single-center 11-year study on a cohort of 118 children.Clinical rheumatology · 2021Article
- Risk factors for intussusception in children with Henoch-Schönlein purpura: A case-control study.World journal of clinical cases · 2021Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Henoch-Schonlein Purpura (HSP) is the most common systemic vasculitis in childhood. The diagnostic criteria include palpable purpura with at least one other manifestation -- abdominal pain, IgA deposition, arthritis or arthralgia, or renal involvement. Immune complex deposits result in necrosis of the wall of small- and medium-sized arteries with infiltration of tissue by neutrophils and deposition of nuclear fragments, a process called leukocytoclastic vasculitis (LCV). It is often associated with infections, medications, or tumors. It may coexist with or mimic Crohn's disease. Periumbilical and epigastric pain worsens with meals, from bowel angina. Bleeding is usually occult or, less commonly, associated with melena. Intussusception, the most common surgical complication, is usually ileo-ileo or ileo-colic. Perforations, usually ileal, may occur spontaneously or be associated with intussusception. Ultrasound, recommended as the first diagnostic test, and CT scans may show intussusception and asymmetric bowel wall thickening mainly involving the jejunum and ileum. There are a range of endoscopic findings including gastritis, duodenitis, ulceration, and purpura, with the second portion of the duodenum characteristically being involved more than the bulb. Intestinal biopsies show IgA deposition and LCV in the submucosal vessels. Superficial biopsies may show inflammation, ulceration, edema, hemorrhage, and vascular congestion, presumably due to vasculitis-induced mucosal ischemia. The efficacy of corticosteroids in preventing severe complications or relapses is controversial. The majority of patients, however, improve spontaneously.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.