ArticleDigestive diseases and sciences2008
Frequency of Helicobacter pylori and CagA antibody in patients with gastric neoplasms and controls: the Indian enigma.
Article in Digestive diseases and sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Spectrum of Primary Gastric Lymphoma in India: A Series of 30 Patients.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- Revisiting Therapeutic Strategies forMolecules (Basel, Switzerland) · 2021Review
- Review
- Management of Helicobacter pylori infection: The Bhubaneswar Consensus Report of the Indian Society of Gastroenterology.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- Oral rinses in growth inhibition and treatment of Helicobacter pylori infection.BMC microbiology · 2020Article
- Novel Insights of Lymphomagenesis ofCancers · 2019Review
- Interactions between Helicobacter pylori and gastroesophageal reflux disease.Esophagus : official journal of the Japan Esophageal Society · 2019Review
- First-line antibiotic therapy in Helicobacter pylori-negative low-grade gastric mucosa-associated lymphoid tissue lymphoma.Scientific reports · 2017Article
- Pepsinogen-II 100 bp ins/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Article
- Helicobacter pylori associated Asian enigma: Does diet deserve distinction?World journal of gastrointestinal oncology · 2016Review
- Nutrition and Helicobacter pylori: Host Diet and Nutritional Immunity Influence Bacterial Virulence and Disease Outcome.Gastroenterology research and practice · 2016Review
- Detection of the Helicobacter pylori CagA protein in gastric mucosa-associated lymphoid tissue lymphoma cells: clinical and biological significance.Blood cancer journal · 2013Article
- Effect of Xeroderma pigmentosum complementation group F polymorphisms and H.pylori infection on the risk of gastric cancer.Pakistan journal of medical sciences · 2013Article
- Asian consensus report on functional dyspepsia.Journal of neurogastroenterology and motility · 2012Article
- Association between gastric mucosal glutathione-S-transferase activity, glutathione-S-transferase gene polymorphisms and Helicobacter pylori infection in gastric cancer.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2011Article
- Patients with Helicobacter pylori infection have less severe gastroesophageal reflux disease: a study using endoscopy, 24-hour gastric and esophageal pH metry.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2011Article
- Gastric cancers of Western European and African patients show different patterns of genomic instability.BMC medical genomics · 2011Article
- Epidemiological review of gastric cancer in India.Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology · 2011Article
- Gastroesophageal Reflux Disease and Helicobacter pylori: What May Be the Relationship?Journal of neurogastroenterology and motility · 2010Article
- The enigma of Helicobacter pylori infection and gastric cancer.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2010Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite association between H. pylori and gastric neoplasm (GN) from the developed world, studies from India, where infection is more common and acquired early, are scant and contradictory.
methodsTwo hundred and seventy-nine patients with GN from two northern and one eastern Indian centers during the period 1997-2005, 101 non-ulcer dyspepsia (NUD), and 355 healthy volunteers (HV) were evaluated for H. pylori [rapid urease test (RUT), histology and anti-H. pylori, and CagA IgG serology].
resultsPatients with GN [263 gastric carcinoma and 16 (6%) primary gastric lymphoma, 208 male] were older than HV (n = 355, 188 male) and NUD (n = 101, 54 male) patients (53 +/- 12 versus 44 +/- 17 and 43 +/- 13 years, respectively; P < 0.001). Eastern Indian patients with GN (n = 145) were younger than those from northern India (n = 134; 52 +/- 12 versus 55 +/- 12 years; P < 0.007, t-test). In GN and NUD patients H. pylori positivity by RUT [86/225 (38%) versus 46/101 (46%)], anti-H. pylori IgG [154/198 (78%) versus 85/101 (84%)], and histology [136/213 (64%) versus 55/101 (55%)] were comparable (chi(2)-test). Serum IgG anti-H. pylori antibody was more common among HV than among GN patients [300/355 (85%) versus 154/198 (78%); P = 0.04, chi(2)-test]. Intestinal metaplasia was more common in GN than in NUD patients [101/252 (40%) versus 2/98 (2%), P < 0.000, chi(2)-test]. CagAIgG was more common in GN than in NUD patients [124/163 (76%) versus 64/101 (63%)] but comparable to that in HV patients [87/98 (89%), P = NS].
conclusionFrequency of H. pylori as detected using endoscopy and serology-based tests is not higher among patients with GN as compared with controls in India.
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