ArticleInternational urogynecology journal and pelvic floor dysfunction2008
Impact of the structure of polypropylene meshes in local tissue reaction: in vivo stereological study.
Article in International urogynecology journal and pelvic floor dysfunction, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00676325 (A Randomized Controlled Trial Study, To Compare Colporrhaphy Versus NAZCA TC™ ,Macroporous Polypropylene Mesh, In Surgical Treatment To Greater Anterior Vaginal Prolapse .), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial Study, To Compare Colporrhaphy Versus NAZCA TC™ ,Macroporous Polypropylene Mesh, In Surgical Treatment To Greater Anterior Vaginal Prolapse .
Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- ComparativeBiomacromolecules · 2024Article
- Structural differences and architectural features of two different polypropylene slings (TVT-O and I-STOP) have no impact on biocompatibility and tissue reactions.Central European journal of urology · 2017Article
- Highly purified collagen coating enhances tissue adherence and integration properties of monofilament polypropylene meshes.International urogynecology journal · 2013Article
- Gluteo-vaginal fistula: a long-term complication of posterior intravaginal slingplasty.BMJ case reports · 2011Article
- Posterior intravaginal slingplasty: efficacy and complications in a continuous series of 118 cases.International urogynecology journal · 2011Article
- Tissue response to a new type of biomaterial implanted subcutaneously in rats.International urogynecology journal · 2011Article
- Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis state of the art.Fibrogenesis & tissue repair · 2009Article
- A new material to prevent urethral damage after implantation of artificial devices: an experimental study.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Effect of platelet-rich plasma on polypropylene meshes implanted in the rabbit vagina: histological analysis.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polypropylene slings are monofilament and multifilament meshes. Their features can impact clinical outcomes. We analyzed tissue reaction, inflammation, and the density of collagen fibers elicited by polypropylene meshes in the subcutaneous tissue of female rats. Thirty female Wistar rats underwent the implantation of 8x4-mm polypropylene meshes (two monofilamentar and two multifilamentar). The rats were killed at 7, 60, and 120 days after implant. Stereology was used to analyze the collagen fiber density. Acute inflammation was more intense in the early post-implant period (p=0.006), except for intravaginal slingplasty (p=0.342). Lymphoplasmocytic reaction was more intense in multifilament samples, even after 60 days (p<0.001) and 120 days (p=0.001). The stereological analysis showed significant differences between mono- and multifilament meshes, considering that monofilament meshes induced more collagen deposition and a greater density of collagen fibers (p<0.001). Multifilament meshes produced a more granulomatous reaction. The collagen fiber density was greater in monofilament meshes, which induced more favorable biocompatibility assessed objectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.