ArticleWorld journal of gastroenterology2008
Intragastric injection of botulinum toxin for the treatment of obesity. Where are we?
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Intragastric Botulinum Toxin A Injection Is an Effective Obesity Therapy for Patients with BMI > 40 kg/mObesity surgery · 2020Pooled it
- Obesity Treatment with Botulinum Toxin-A Is Not Effective: a Systematic Review and Meta-Analysis.Obesity surgery · 2017Pooled it
- Advances and future directions in endoscopic bariatric therapies.World journal of gastrointestinal endoscopy · 2025Review
- Endoscopic bariatrics: Current status and emerging technologies.World journal of gastrointestinal endoscopy · 2025Review
- Evaluating the efficacy of intragastric botulinum toxin a injections with two different quantities and sites for obesity.PloS one · 2025Article
- Intragastric botulinum toxin injection: a promising alternative for obesity treatment?Archives of medical science : AMS · 2024Article
- An Assessment of the Quality and Reliability of Gastric Botox Information Videos on YouTube.Cureus · 2023Article
- How Taking into Account the Pyloric Tonus Contributes to Treatment Success While Administering Gastric "Botulinum Toxin A" for Weight Loss.Obesity surgery · 2020Article
- Endoscopic Interventions in the Treatment of Obesity and Diabetes.Digestive diseases and sciences · 2018Review
- Botulinum Toxin A for Controlling Obesity.Toxins · 2016Review
- An update on less invasive and endoscopic techniques mimicking the effect of bariatric surgery.Journal of obesity · 2012Article
- Endoscopic treatment of obesity.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2011Review
- Review
- Comparison of safety and efficacy of intragastric botulinum toxin-A versus gastric balloon.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- Can gastric botulinum toxin A injection be used as minimally invasive procedure in the short-term treatment of obesity?Journal of minimal access surgeryArticle
- Procedures and devices for bariatric and metabolic endoscopy.Therapeutic advances in gastrointestinal endoscopyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity has reached epidemic proportions particularly in western countries. Most non-surgical treatments of this condition are disappointing. Since 2005, several studies evaluating the effect of Botulinum Toxin type A (BT-A) in gastric antrum by means of endoscopy for the treatment of obesity have been published. This treatment modality was based on the observation that gastric injection of BT-A in laparatomized rats induced a significant reduction of food intake and body weight. Nowadays, 6 studies have been published yielding conflicting results. Differences in selection of patients, doses of BT-A, method of administration of the toxin and instruments of evaluation of some parameters among these studies may be the cause of divergent results. We discuss herein some important features of these studies pointing out on differences among them. At the same time, based on the knowledge of physiological characteristics of normal and abnormal gastric function related with feeding, we discuss the probable causes of failure observed in these trials. Finally, we give some guidelines concerning the way that future research in this field may follow, not without calling attention to disadvantages of this treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.