ArticleLipids2008
A pivotal role of the human kidney in catabolism of HDL protein components apolipoprotein A-I and A-IV but not of A-II.
Article in Lipids, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Lifestyles, metabolome and diabetic kidney disease: a cohort study.QJM : monthly journal of the Association of Physicians · 2026Article
- High Density Lipoprotein Particle Composition, Functionality, Deficiency, and Atherosclerotic Cardiovascular Disease Risk: A Review.Current atherosclerosis reports · 2025Review
- Association of HDL Subfraction Profile with the Progression of Insulin Resistance.International journal of molecular sciences · 2023Article
- Engineered rHDL Nanoparticles as a Suitable Platform for Theranostic Applications.Molecules (Basel, Switzerland) · 2022Article
- High-Density Lipoproteins in Kidney Disease.International journal of molecular sciences · 2021Review
- Multifaced Roles of HDL in Sepsis and SARS-CoV-2 Infection: Renal Implications.International journal of molecular sciences · 2021Review
- Urinary apolipoprotein AI in children with kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Article
- Lipoprotein modulation of proteinuric renal injury.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- TNF-α-induced Inflammation Stimulates Apolipoprotein-A4 via Activation of TNFR2 and NF-κB Signaling in Kidney Tubular Cells.Scientific reports · 2017Article
- Increased expression of ApoA1 after neuronal injury may be beneficial for healing.Molecular and cellular biochemistry · 2017Article
- High-Density Lipoprotein, Lecithin: Cholesterol Acyltransferase, and Atherosclerosis.Endocrinology and metabolism (Seoul, Korea) · 2016Review
- Kidneys: key modulators of high-density lipoprotein levels and function.Current opinion in nephrology and hypertension · 2016Review
- Article
- Residual Cardiovascular Risk in Chronic Kidney Disease: Role of High-density Lipoprotein.Archives of medical research · 2015Review
- Associations of genetic polymorphisms of SAA1 with cerebral infarction.Lipids in health and disease · 2013Article
- Factors controlling nascent high-density lipoprotein particle heterogeneity: ATP-binding cassette transporter A1 activity and cell lipid and apolipoprotein AI availability.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Associations of SAA1 gene polymorphism with lipid lelvels and osteoporosis in Chinese women.Lipids in health and disease · 2013Article
- HDL dysfunction in diabetes: causes and possible treatments.Expert review of cardiovascular therapy · 2012Review
- Article
- Lower HDL-C and apolipoprotein A-I are related to higher glomerular filtration rate in subjects without kidney disease.Journal of lipid research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal handling of major HDL components was studied by analyzing urine from patients with Fanconi syndrome, a rare renal proximal tubular reabsorption failure, including dysfunction of the kidney HDL receptor, cubilin. A high urinary excretion of apolipoprotein A-I and A-IV corresponding to a major part of the metabolism of these proteins was measured. In contrast, no urinary excretion of apolipoprotein A-II which is more hydrophobic and tighter bound to HDL was found. Control urines displayed absence of the three apolipoproteins. Urinary excretion of phospholipids, triglycerides, cholesterol and cholesterol esters in patients was as low as in controls. In conclusion, these data indicate that the human kidney is a major site for filtered nascent apolipoprotein A-I and A-IV but not for HDL particles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.