ArticlePloS one2008
Nitric oxide antagonizes the acid tolerance response that protects Salmonella against innate gastric defenses.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
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- On the difficult evolutionary transition from the free-living lifestyle to obligate symbiosis.PloS one · 2020Article
- Spx, a versatile regulator of the Bacillus subtilis stress response.Current genetics · 2019Review
- Article
- The Small RNA DsrA Influences the Acid Tolerance Response and Virulence of Salmonella enterica Serovar Typhimurium.Frontiers in microbiology · 2016Article
- Stress response of Salmonella enterica serovar typhimurium to acidified nitrite.Applied and environmental microbiology · 2014Article
- The 4-cysteine zinc-finger motif of the RNA polymerase regulator DksA serves as a thiol switch for sensing oxidative and nitrosative stress.Molecular microbiology · 2014Article
- Salmonella utilizes D-glucosaminate via a mannose family phosphotransferase system permease and associated enzymes.Journal of bacteriology · 2013Article
- S-bacillithiolation protects conserved and essential proteins against hypochlorite stress in firmicutes bacteria.Antioxidants & redox signaling · 2013Article
- Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria.Frontiers in cellular and infection microbiology · 2013Review
- Cysteine catabolism and cysteine desulfhydrase (CdsH/STM0458) in Salmonella enterica serovar typhimurium.Journal of bacteriology · 2012Article
- DksA-dependent resistance of Salmonella enterica serovar Typhimurium against the antimicrobial activity of inducible nitric oxide synthase.Infection and immunity · 2012Article
- Inhibited Production of iNOS by Murine J774 Macrophages Occurs via a phoP-Regulated Differential Expression of NFκB and AP-1.Interdisciplinary perspectives on infectious diseases · 2012Article
- DNA damage and reactive nitrogen species are barriers to Vibrio cholerae colonization of the infant mouse intestine.PLoS pathogens · 2011Article
- Nitric oxide and salmonella pathogenesis.Frontiers in microbiology · 2011Article
- Fur negatively regulates hns and is required for the expression of HilA and virulence in Salmonella enterica serovar Typhimurium.Journal of bacteriology · 2011Article
- Control of redox balance by the stringent response regulatory protein promotes antioxidant defenses of Salmonella.The Journal of biological chemistry · 2010Article
- Redox sensor SsrB Cys203 enhances Salmonella fitness against nitric oxide generated in the host immune response to oral infection.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Life in the gut: microbial responses to stress in the gastrointestinal tract.Science progress · 2010Review
- Codependent and independent effects of nitric oxide-mediated suppression of PhoPQ and Salmonella pathogenicity island 2 on intracellular Salmonella enterica serovar typhimurium survival.Infection and immunity · 2009Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundReactive nitrogen species (RNS) derived from dietary and salivary inorganic nitrogen oxides foment innate host defenses associated with the acidity of the stomach. The mechanisms by which these reactive species exert antimicrobial activity in the gastric lumen are, however, poorly understood. METHODOLOGY/PRINCIPAL
findingsThe genetically tractable acid tolerance response (ATR) that enables enteropathogens to survive harsh acidity was screened for signaling pathways responsive to RNS. The nitric oxide (NO) donor spermine NONOate derepressed the Fur regulon that controls secondary lines of resistance against organic acids. Despite inducing a Fur-mediated adaptive response, acidified RNS largely repressed oral virulence as demonstrated by the fact that Salmonella bacteria exposed to NO donors during mildly acidic conditions were shed in low amounts in feces and exhibited ameliorated oral virulence. NO prevented Salmonella from mounting a de novo ATR, but was unable to suppress an already functional protective response, suggesting that RNS target regulatory cascades but not their effectors. Transcriptional and translational analyses revealed that the PhoPQ signaling cascade is a critical ATR target of NO in rapidly growing Salmonella. Inhibition of PhoPQ signaling appears to contribute to most of the NO-mediated abrogation of the ATR in log phase bacteria, because the augmented acid sensitivity of phoQ-deficient Salmonella was not further enhanced after RNS treatment. CONCLUSIONS/SIGNIFICANCE: Since PhoPQ-regulated acid resistance is widespread in enteric pathogens, the RNS-mediated inhibition of the Salmonella ATR described herein may represent a common component of innate host defenses.
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