ArticlePloS one2008
Association of a bovine prion gene haplotype with atypical BSE.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Short incubation periods of atypical H-type BSE in cattle with EK211 and KK211 prion protein genotypes after intracranial inoculation.Frontiers in veterinary science · 2023Article
- A Review of Selected Genes with Known Effects on Performance and Health of Cattle.Frontiers in veterinary science · 2016Review
- Genetics of Prion Disease in Cattle.Bioinformatics and biology insights · 2015Review
- Identification of H-type BSE in Portugal.Prion · 2015Article
- Genetic diversity in the prion protein gene (PRNP) of domestic cattle and water buffaloes in Vietnam, Indonesia and Thailand.The Journal of veterinary medical science · 2014Article
- Experimental H-type bovine spongiform encephalopathy characterized by plaques and glial- and stellate-type prion protein deposits.Veterinary research · 2011Article
- Scientific Opinion on the review on the risk for human and animal health related to the revision of the BSE monitoring regime in three EU Member States.EFSA journal. European Food Safety Authority · 2011Article
- Article
- Frequencies of polymorphisms associated with BSE resistance differ significantly between Bos taurus, Bos indicus, and composite cattle.BMC veterinary research · 2008Article
- BSE case associated with prion protein gene mutation.PLoS pathogens · 2008Article
- Article
- Prevalence of the prion protein gene E211K variant in U.S. cattle.BMC veterinary research · 2008Article
- Risk for Human and Animal Health related to the revision of the BSE Monitoring regime in some Member States - Scientific Opinion.EFSA journal. European Food Safety Authority · 2008Article
- A sequencing strategy for identifying variation throughout the prion gene of BSE-affected cattle.BMC research notes · 2008Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtypical bovine spongiform encephalopathies (BSEs) are recently recognized prion diseases of cattle. Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with atypical BSE. METHODOLOGY/PRINCIPLE
findingsHaplotype tagging polymorphisms that characterize PRNP haplotypes from the promoter region through the three prime untranslated region of exon 3 (25.2 kb) were used to determine PRNP haplotypes of six available atypical BSE cases from Canada, France and the United States. One or two copies of a distinct PRNP haplotype were identified in five of the six cases (p = 1.3 x 10(-4), two-tailed Fisher's exact test; CI(95%) 0.263-0.901, difference between proportions). The haplotype spans a portion of PRNP that includes part of intron 2, the entire coding region of exon 3 and part of the three prime untranslated region of exon 3 (13 kb). CONCLUSIONS/SIGNIFICANCE: This result suggests that a genetic determinant in or near PRNP may influence susceptibility of cattle to atypical BSE.
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