ArticlePloS one2008
Association of the estrogen receptor 1 (ESR1) gene with body height in adult males from two Swedish population cohorts.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
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- Integrative transcriptomic analysis reveals novel targets for personalized medicine across seven metastatic breast cancer subtypes.Scientific reports · 2026Article
- Estrogen Receptor 1 Gene Polymorphism and its Association with Idiopathic Short Stature in a North Indian PopulationJournal of clinical research in pediatric endocrinology · 2024Article
- Convergent dwarfism consequences of minipigs under independent artificial selections.BMC genomics · 2024Article
- Sequencing of Chromosomal Locus 6q25.1 Revealed Two Significant SNPs rs2046210 and rs2046211 Associated with Breast Cancer: A Case-Control Study in Egyptian Women.Asian Pacific journal of cancer prevention : APJCP · 2022Article
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- Identification of Genomic Characteristics and Selective Signals in a Du'an Goat Flock.Animals : an open access journal from MDPI · 2020Article
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- Epigenetic heredity of human height.Physiological reports · 2014Article
- Structural maintenance of chromosome complexes and bone development: the beginning of a wonderful relationship?BoneKEy reports · 2013Article
- Interactive effect of genetic susceptibility with height, body mass index, and hormone replacement therapy on the risk of breast cancer.BMC women's health · 2012Article
- LCT 13910 C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2009Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human body height is a complex genetic trait with high heritability. We performed an association study of 17 candidate genes for height in the Uppsala Longitudinal Study of Adult Men (ULSAM) that consists of 1153 elderly men of age 70 born in the central region of Sweden. First we genotyped a panel of 137 single nucleotide polymorphism (SNPs) evenly distributed across the candidate genes in the ULSAM cohort. We identified 4 SNPs in the estrogen receptor gene (ESR1) on chromosome 6q25.1 with suggestive signals of association (p<0.05) with standing body height. This result was followed up by genotyping the same 25 SNPs in the ESR1 gene as in ULSAM in a second population cohort, the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort that consist of 507 males and 509 females of age 70 from the same geographical region as ULSAM. One SNP, rs2179922 located in intron 4 of ESR1 showed and association signal (p = 0.0056) in the male samples from the PIVUS cohort. Homozygote carriers of the G-allele of the SNP rs2179922 were on average 0.90 cm taller than individuals with the two other genotypes at this SNP in the ULSAM cohort and 2.3 cm taller in the PIVUS cohort. No association was observed for the females in the PIVUS cohort.
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