ArticlePloS one2008
Validity of the common cold questionnaire (CCQ) in asthma exacerbations.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Inhaled Ciclesonide for Community-Based COVID-19: A Placebo-Controlled Randomised Trial.Respirology (Carlton, Vic.) · 2026Trial
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- A prospective study of respiratory viral infection in pregnant women with and without asthma.Chest · 2013Trial
- Effect of the health and wellness Kneipp concept on health promotion and reduction of sick days for kindergarten children: a cluster randomized controlled trial protocol.Frontiers in medicine · 2024Article
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- Changes in Perceived Stress and Lifestyle Behaviors in Response to the COVID-19 Pandemic in The Netherlands: An Online Longitudinal Survey Study.International journal of environmental research and public health · 2022Article
- A syndromic approach to assess diagnosis and management of patients presenting with respiratory symptoms to healthcare facilities in Vietnam.ERJ open research · 2021Article
- Nasal epithelial cells to assess in vitro immune responses to respiratory virus infection in pregnant women with asthma.Respiratory research · 2019Article
- Asymptomatic Shedding of Respiratory Virus among an Ambulatory Population across Seasons.mSphere · 2018Article
- Viruses in bronchiectasis: a pilot study to explore the presence of community acquired respiratory viruses in stable patients and during acute exacerbations.BMC pulmonary medicine · 2018Article
- Asymptomatic Summertime Shedding of Respiratory Viruses.The Journal of infectious diseases · 2018Article
- Nasopharyngeal isolates and their clinical impact on young children with asthma: a pilot study.Journal of asthma and allergy · 2018Article
- Health symptoms in relation to temperature, humidity, and self-reported perceptions of climate in New York City residential environments.International journal of biometeorology · 2017Article
- Psychosocial mechanisms for the transmission of somatic symptoms from parents to children.World journal of gastroenterology · 2015Article
- Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma.The Journal of allergy and clinical immunology · 2015Article
- Asthma in pregnancy: a hit for two.European respiratory review : an official journal of the European Respiratory Society · 2014Review
- Respiratory viral infections in pregnant women with asthma are associated with wheezing in the first 12 months of life.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe common cold questionnaire (CCQ) is used to discriminate those with and without a viral infection. Its usefulness in people with acute asthma is unknown. Our aim was to assess the ability of the CCQ to detect viral infection and to monitor recovery during a viral induced asthma exacerbation and confirmed by virological testing. METHODOLOGY/PRINCIPAL
findingsWe studied subjects (> or =7 yrs) admitted to hospital with acute asthma and diagnosed as positive (n = 63), or negative to viral infection (n = 27) according to molecular and virological testing from respiratory samples. CCQ, asthma history and asthma control questionnaires were completed and repeated 4-6 weeks later. Sensitivity, specificity, and response to change of the CCQ were assessed by receiver operator curve (ROC) analysis and effect size calculation respectively. The CCQ did not discriminate between viral and non-viral infection for subjects with asthma (sensitivity = 76.2%; specificity = 29.6%). ROC analysis could not differentiate between positive or negative virus in subjects with asthma. The CCQ had a large response to change following recovery (effect size = 1.01). 39% of subjects recovering from viral exacerbation remained positive to virological testing at follow-up despite improvement in clinical symptoms. The CCQ reflected clinical improvement in these subjects, thus providing additional information to complement virological testing. CONCLUSIONS/SIGNIFICANCE: The CCQ is a useful instrument for monitoring response to viral infection in people with asthma. Reliable differentiation between viral and non-viral asthma exacerbations was not achieved with the CCQ and requires specific virological testing. When combined with virological testing, the CCQ should be a useful outcome measure for evaluating therapies in viral-induced asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.