ArticlePloS one2008
Clinical and microbiological features of HIV-associated tuberculous meningitis in Vietnamese adults.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Treatment outcomes of tuberculous meningitis in adults: a systematic review and meta-analysis.BMC pulmonary medicine · 2019Pooled it
- Systematic review of tuberculous meningitis in high-risk populations: mortality and diagnostic disparities.Future microbiologyPooled it
- Influence of antituberculosis drug resistance and Mycobacterium tuberculosis lineage on outcome in HIV-associated tuberculous meningitis.Antimicrobial agents and chemotherapy · 2012Trial
- Timing of initiation of antiretroviral therapy in human immunodeficiency virus (HIV)--associated tuberculous meningitis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011Trial
- Trial
- Clinical features, resistance patterns and treatment outcomes of drug-resistant extra-pulmonary tuberculosis: A scoping review.Journal of clinical tuberculosis and other mycobacterial diseases · 2023Article
- Tuberculous Meningitis in Children: Reducing the Burden of Death and Disability.Pathogens (Basel, Switzerland) · 2021Review
- Cerebrospinal Fluid Bacillary Load by Xpert MTB/RIF Ultra Polymerase Chain Reaction Cycle Threshold Value Predicts 2-Week Mortality in Human Immunodeficiency Virus-Associated Tuberculous Meningitis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Human Fungal Infections in Kuwait-Burden and Diagnostic Gaps.Journal of fungi (Basel, Switzerland) · 2020Article
- Treatment Outcomes in Adult Tuberculous Meningitis: A Systematic Review and Meta-analysis.Open forum infectious diseases · 2020Article
- The pathogenesis of tuberculous meningitis.Journal of leukocyte biology · 2019Review
- Neurocognitive and functional impairment in adult and paediatric tuberculous meningitis.Wellcome open research · 2019Review
- The current global situation for tuberculous meningitis: epidemiology, diagnostics, treatment and outcomes.Wellcome open research · 2019Review
- A New Scoring System for the Differential Diagnosis between Tuberculous Meningitis and Viral Meningitis.Journal of Korean medical science · 2018Article
- Estimation of the Burden of Serious Human Fungal Infections in Malaysia.Journal of fungi (Basel, Switzerland) · 2018Article
- Prognostic Models for 9-Month Mortality in Tuberculous Meningitis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Review
- Standardized Methods for Enhanced Quality and Comparability of Tuberculous Meningitis Studies.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Review
- Clinical presentations, diagnosis, mortality and prognostic markers of tuberculous meningitis in Vietnamese children: a prospective descriptive study.BMC infectious diseases · 2016Article
- Six months therapy for tuberculous meningitis.The Cochrane database of systematic reviews · 2016Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
methodsThe aim of this prospective, observational cohort study was to determine the clinical and microbiological features, outcome, and baseline variables predictive of death, in Vietnamese adults with HIV-associated tuberculous meningitis (TBM). 58 patients were admitted to the Hospital for Tropical Diseases in Ho Chi Minh City and underwent routine clinical and laboratory assessments. Treatment was with standard antituberculous therapy and adjunctive dexamethasone; antiretroviral therapy was not routinely available. Patients were followed up until the end of TB treatment or death.
resultsThe median symptom duration was 11 days (range 2-90 days), 21.8% had a past history of TB, and 41.4% had severe (grade 3) TBM. The median CD4 count was 32 cells/mm(3). CSF findings were as follows: median leucocyte count 438 x 10(9)cells/l (63% neutrophils), 69% smear positive and 87.9% culture positive. TB drug resistance rates were high (13% mono-resistance 32.6% poly-resistance 8.7% multidrug resistance). 17% patients developed further AIDS-defining illnesses. 67.2% died (median time to death 20 days). Three baseline variables were predictive of death by multivariate analysis: increased TBM grade [adjusted hazard ratio (AHR) 1.73, 95% CI 1.08-2.76, p = 0.02], lower serum sodium (AHR 0.93, 95% CI 0.89 to 0.98, p = 0.002) and decreased CSF lymphocyte percentage (AHR 0.98, 95% CI 0.97 to 0.99, p = 0.003).
conclusionsHIV-associated TBM is devastating disease with a dismal prognosis. CSF findings included CSF neutrophil predominance, high rates of smear and culture positivity, and high rates of antituberculous drug resistance. Three baseline variables were independently associated with death: increased TBM grade; low serum sodium and decreased CSF lymphocyte percentage.
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Registered trials
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