ArticleProceedings. Biological sciences2008
Residual force enhancement in myofibrils and sarcomeres.
Article in Proceedings. Biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.
- Residual force enhancement in human skeletal muscles: A systematic review and meta-analysis.Journal of sport and health science · 2022Pooled it
- Trial
- Mechanical loading and fatigue-induced changes in triceps surae muscle-tendon unit: sex-specific responses and recovery dynamics.Frontiers in physiology · 2026Article
- Residual force enhancement following hindlimb unloading and exercise prehabilitation.Journal of muscle research and cell motility · 2025Article
- Modulation of stretch activation influences the stretch-shortening cycle effect in in vivo human knee extensors.Physiological reports · 2025Article
- Residual force enhancement is not altered while force depression is amplified at the cellular level in old age.The Journal of experimental biology · 2025Article
- Characterizing residual and passive force enhancements in cardiac myofibrils.Biophysical journal · 2023Article
- Measurements of tendon length changes during stretch-shortening cycles in rat soleus.Scientific reports · 2023Article
- Eccentric exercise-induced muscle weakness amplifies the history dependence of force.European journal of applied physiology · 2023Article
- Eccentric muscle contractions: from single muscle fibre to whole muscle mechanics.Pflugers Archiv : European journal of physiology · 2023Review
- Gaining new understanding of sarcomere length non-uniformities in skeletal muscles.Frontiers in physiology · 2023Article
- Effect of Active Lengthening and Shortening on Small-Angle X-ray Reflections in Skinned Skeletal Muscle Fibres.International journal of molecular sciences · 2021Article
- Sarcomere length non-uniformities dictate force production along the descending limb of the force-length relation.Proceedings. Biological sciences · 2020Article
- Motor unit contributions to activation reduction and torque steadiness following active lengthening: a study of residual torque enhancement.Journal of neurophysiology · 2020Article
- Cross-Bridges and Sarcomeric Non-cross-bridge Structures Contribute to Increased Work in Stretch-Shortening Cycles.Frontiers in physiology · 2020Article
- Sarcomere Lengths Become More Uniform Over Time in Intact Muscle-Tendon Unit During Isometric Contractions.Frontiers in physiology · 2020Article
- Energy Cost of Force Production After a Stretch-Shortening Cycle in Skinned Muscle Fibers: Does Muscle Efficiency Increase?Frontiers in physiology · 2020Article
- Evidence for Muscle Cell-Based Mechanisms of Enhanced Performance in Stretch-Shortening Cycle in Skeletal Muscle.Frontiers in physiology · 2020Review
- Pre-activation affects the effect of stretch-shortening cycle by modulating fascicle behavior.Biology open · 2019Article
- Influence of muscle length on the stretch-shortening cycle in skinned rabbit soleus.Scientific reports · 2019Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Residual force enhancement has been observed following active stretch of skeletal muscles and single fibres. However, there has been intense debate whether force enhancement is a sarcomeric property, or is associated with sarcomere length instability and the associated development of non-uniformities. Here, we studied force enhancement for the first time in isolated myofibrils (n=18) that, owing to the strict in series arrangement, allowed for evaluation of this property in individual sarcomeres (n=79). We found consistent force enhancement following stretch in all myofibrils and each sarcomere, and forces in the enhanced state typically exceeded the isometric forces on the plateau of the force-length relationship. Measurements were made on the plateau and the descending limb of the force-length relationship and revealed gross sarcomere length non-uniformities prior to and following active myofibril stretching, but in contrast to previous accounts, revealed that sarcomere lengths were perfectly stable under these experimental conditions. We conclude that force enhancement is a sarcomeric property that does not depend on sarcomere length instability, that force enhancement varies greatly for different sarcomeres within the same myofibril and that sarcomeres with vastly different amounts of actin-myosin overlap produce the same isometric steady-state forces. This last finding was not explained by differences in the amount of contractile proteins within sarcomeres, vastly different passive properties of individual sarcomeres or (half-) sarcomere length instabilities, suggesting that the basic mechanical properties of muscles, such as force enhancement, force depression and creep, which have traditionally been associated with sarcomere instabilities and the corresponding dynamic redistribution of sarcomere lengths, are not caused by such instabilities, but rather seem to be inherent properties of the mechanisms of contraction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.