ArticleJournal of the Royal Society, Interface2008
Prevalence of sheep infected with classical scrapie in Great Britain: integrating multiple sources of surveillance data for 2002.
Article in Journal of the Royal Society, Interface, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Impact of Removing the Monitoring Requirements for Holdings with Atypical Scrapie in Great Britain.Animals : an open access journal from MDPI · 2024Article
- Evidence for more cost-effective surveillance options for bovine spongiform encephalopathy (BSE) and scrapie in Great Britain.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017Article
- Article
- Scrapie prevalence in sheep of susceptible genotype is declining in a population subject to breeding for resistance.BMC veterinary research · 2010Article
- Associations between lamb survival and prion protein genotype: analysis of data for ten sheep breeds in Great Britain.BMC veterinary research · 2009Article
- The role of mathematical modelling in understanding the epidemiology and control of sheep transmissible spongiform encephalopathies: a review.Veterinary researchReview
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Authors and funding
1 author.
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Abstract
Estimates for the prevalence of sheep infected with classical scrapie are essential for assessing the efficacy of control strategies that have been implemented in Great Britain (GB). Here a back-calculation approach was used to estimate the prevalence in the GB national flock by integrating data on reported cases and the results of abattoir and fallen stock surveys for 2002. Prevalence estimates ranged from 0.33 to 2.06%, depending on the estimates used for the frequencies of prion protein (PrP) genotypes in the national flock and the stage of incubation at which the diagnostic tests used are able to detect infected animals. The risk of infection was found to be higher than that of clinical disease, especially in those PrP genotypes that have a later age at onset of clinical disease. Moreover, results suggest that a high proportion (more than 55%) of infected animals surviving to disease onset die on farm before clinical signs become apparent, which helps account for the high observed prevalence in the fallen stock compared with the abattoir survey. The analyses indicated that attention needs to be given to identifying the stage of incubation at which diagnostic tests are able to detect infected animals and obtaining better demographic data for the GB national flock.
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