ArticlePathology oncology research : POR2008
Tumor characteristics in screen-detected and symptomatic breast cancers.
Article in Pathology oncology research : POR, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 69 citations in OpenAlex.
- Screen-Detected Breast Cancer Outcomes by Mammography Participation in Immediate Past Screening.JAMA network open · 2025Article
- Screening History, Stage at Diagnosis, and Mortality in Screen-Detected Breast Cancer.JAMA network open · 2025Article
- Article
- Clinicopathological and molecular differences between stage IV screen-detected and interval colorectal cancers in the Flemish screening program.Frontiers in oncology · 2024Article
- The dilemma of recalling well-circumscribed masses in a screening population: A narrative literature review and exploration of Dutch screening practice.Breast (Edinburgh, Scotland) · 2023Review
- Breast cancer screening of mutation carriers in the era of COVID-19 pandemic.International journal of cancer · 2020Article
- Low Prevalence of HER2-Positive Breast Carcinomas among Screening Detected Breast Cancers.Cancers · 2020Article
- Interval breast cancer is associated with other types of tumors.Nature communications · 2019Article
- Organized screening detects breast cancer at earlier stage regardless of molecular phenotype.Journal of cancer research and clinical oncology · 2018Article
- Differences in subtype distribution between screen-detected and symptomatic invasive breast cancer and their impact on survival.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Article
- Biological characteristics of interval cancers: a role for biomarkers in the breast cancer screening.Journal of cancer research and clinical oncology · 2013Article
- Molecular profiles of screen detected vs. symptomatic breast cancer and their impact on survival: results from a clinical series.BMC cancer · 2013Article
- The burden of breast cancer in Italy: mastectomies and quadrantectomies performed between 2001 and 2008 based on nationwide hospital discharge records.Journal of experimental & clinical cancer research : CR · 2012Article
- Symptomatic metastasis prediction with serial measurements of CA 15.3 in primary breast cancer patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- Mammographic density and hormone receptor expression in breast cancer: the Multiethnic Cohort Study.Cancer epidemiology · 2011Article
- Long-term prognosis of breast cancer detected by mammography screening or other methods.Breast cancer research : BCR · 2011Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The natural course of early breast cancer has changed as a result of the introduction of mammographic screening. The present aim was a prospective analysis of screen-detected and symptomatic operable breast cancers in the era of mammographic service screening. The mode of detection (screen-detected, symptomatic or interval cancer), the type of mammographic image and other characteristics (the invasive tumor size, histological tumor type, grade, nodal, hormone receptor and HER2 status and the presence of lymphovascular invasion) of 569 invasive breast cancers were studied. Screen-detected cancers were significantly more frequently of grade I, < 10 mm of size and node-negative (p < 0.001, respectively). Symptomatic/interval cancers were significantly more frequently of grade 3, >20 mm of size (p < 0.001), and exhibited lymphovascular invasion (p = 0.001). Screening-detection of the tumor favored breast-conserving surgery, sentinel lymph node biopsy and the avoidance of chemotherapy (p < 0.001). Cancers associated with casting-type calcifications on the mammogram were typically of ductal type (p = 0.043), of grade 2-3, estrogen receptor and progesterone receptor-negative and HER2-positive (p < 0.001). Interval cancers occurred significantly more often at a younger age and remained mammographically occult as compared with other cancers. Mammographic screen-detected cancers demonstrate more favorable prognostic features, and need less extensive treatment than symptomatic or interval cancers. The mammographic appearance of the tumor reflects its biological behavior, and this should be considered in the management optimization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.